Proliferating cell nuclear antigen (PCNA) expression in patients with breast carcinoma in comparison to patients with benign breast diseases

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dc.contributor.authorKalogeraki, A.en
dc.contributor.authorTzardi, M.en
dc.contributor.authorDatseris, G.en
dc.contributor.authorKanavaros, P.en
dc.contributor.authorKarvelas, C.en
dc.contributor.authorChalkiadakis, G.en
dc.contributor.authorTsiftsis, D.en
dc.contributor.authorDelides, G.en
dc.date.accessioned2015-11-24T18:56:09Z
dc.date.available2015-11-24T18:56:09Z
dc.identifier.issn0258-851X-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/18991
dc.rightsDefault Licence-
dc.subjectBiopsy, Needle/methodsen
dc.subjectBreast Neoplasms/*metabolismen
dc.subjectCarcinoma, Ductal, Breast/*metabolismen
dc.subjectFemaleen
dc.subjectFibroadenoma/*metabolismen
dc.subjectFibrocystic Breast Disease/*metabolismen
dc.subjectHumansen
dc.subjectProliferating Cell Nuclear Antigen/*biosynthesisen
dc.titleProliferating cell nuclear antigen (PCNA) expression in patients with breast carcinoma in comparison to patients with benign breast diseasesen
heal.abstractThe proliferating cell nuclear antigen (PCNA) was studied by immunohistochemistry on FNA specimens of 20 breast (ductal) carcinomas, 20 fibroadenomas and 20 atypical fibrocystic lesions of the breast. Sixteen cases of breast carcinomas, eight fibroadenomas but no atypical fibrocystic lesions were found to display nuclear PCNA staining. A significant difference was found, between PCNA index of breast carcinomas (mean PCNA index 56%) and fibroadenomas (mean PCNA 21, 25%). This suggests that breast carcinomas display a higher proliferation index than fibroadenomas and fibrocystic disease. Furthermore, we found variations in PCNA among individual cases of breast carcinomas. This suggests that PCNA index can help in the individual approach of the proliferation rate of each tumour, a parameter of potentially importance for predicting the biological behaviour of the tumour in association with other proliferation markers.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/7772736-
heal.journalNameIn Vivoen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1994-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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