External beam irradiation following balloon angioplasty in an atherosclerotic rabbit model

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dc.contributor.authorKalef-Ezra, J.en
dc.contributor.authorMichalis, L. K.en
dc.contributor.authorTsekeris, P.en
dc.contributor.authorGloutsianou, G.en
dc.contributor.authorKatsouras, C.en
dc.contributor.authorVardakas, D.en
dc.contributor.authorBoziari, A.en
dc.contributor.authorToumpoulis, G.en
dc.contributor.authorNikou, D.en
dc.contributor.authorMalamou-Mitsi, V.en
dc.contributor.authorSideris, D. A.en
dc.date.accessioned2015-11-24T19:16:24Z
dc.date.available2015-11-24T19:16:24Z
dc.identifier.issn1522-1865-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21659
dc.rightsDefault Licence-
dc.subject*Angioplasty, Balloonen
dc.subjectAnimalsen
dc.subjectArteriosclerosis/*radiotherapy/therapyen
dc.subjectFemoral Artery/*injuries/*radiation effectsen
dc.subjectHypercholesterolemia/pathologyen
dc.subjectMaleen
dc.subjectRabbitsen
dc.subjectRadiation Dosageen
dc.subject*Radiotherapy, High-Energyen
dc.titleExternal beam irradiation following balloon angioplasty in an atherosclerotic rabbit modelen
heal.abstractPURPOSE: To study the effect of external beam irradiation on the morphometry of both angioplasted and nonangioplasted arteries in a hypercholesterolemic rabbit model. METHODS AND MATERIALS: Four groups of rabbit femoral arteries were studied: arteries (a) with no intervention, (b) irradiated with a 12-Gy x-ray dose, (c) treated with balloon angioplasty, and (d) dosed with 12 Gy 30 min after balloon angioplasty. RESULTS: External irradiation did not change vessel morphometry in nonangioplasted arteries. On the contrary, it induced neointimal formation and decreased luminal area, without causing any vessel remodeling in arteries treated with balloon angioplasty. CONCLUSION: External irradiation at 12 Gy given 30 min after angioplasty in the studied model accentuated the neointimal response to vascular injury, without causing any vessel remodeling.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/10828564-
heal.identifier.secondaryhttp://ac.els-cdn.com/S1522186500000275/1-s2.0-S1522186500000275-main.pdf?_tid=3014217c7a6614bf7cfb7aad9fbc0afa&acdnat=1337844404_ca06192a9d85303cfd0dc3b37fe021ef-
heal.journalNameCardiovasc Radiat Meden
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1999-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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