Platinum(II) complexes with 2-acetyl pyridine thiosemicarbazone. Synthesis, crystal structure, spectral properties, antimicrobial and antitumour activity
Φόρτωση...
Ημερομηνία
Συγγραφείς
Kovala-Demertzi, D.
Demertzis, M. A.
Miller, J. R.
Papadopoulou, C.
Dodorou, C.
Filousis, G.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
J Inorg Biochem
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
An interesting series of new platinum complexes has been synthesized by the reaction of Na(2)PtCl(4) with 2-acetyl pyridine thiosemicarbazone, HAcTsc. The new complexes, [Pt(AcTsc)Cl], [Pt(HAcTsc)(2)]Cl(2) and [Pt(AcTsc)(2)], have been characterized by elemental analyses and spectroscopic studies. The crystal structure of the complex [Pt(AcTsc)Cl] has been solved by single-crystal X-ray diffraction. The anion of HAcTsc coordinates in a planar conformation to the central platinum(II) through the pyridyl N, azomethine N and thiolato S atoms. Double intermolecular hydrogen bonds (NH-Cl), pi-pi and weak Pt-Pt and Pt-pi contacts lead to aggregation and to a two-dimensional supramolecular assembly. The antibacterial and antifungal effect of the novel platinum(II) complexes and the related palladium(II) complexes, [Pd(AcTsc)Cl], [Pd(HAcTsc)(2)]Cl(2) and [Pd(AcTsc)(2)], were studied in vitro. The complexes were found to have a completely lethal effect on Gram+ bacteria, while the same complexes showed no bactericidal effect on Gram- bacteria. Additionally, the complexes [Pt(AcTsc)(2)] and [Pd(AcTsc)(2)] showed effective antifungal activity towards yeast. Among these compounds [33], the most effective in inducing antitumour and cytogenetic effects are the complexes [Pt(AcTsc)(2)] and [Pd(AcTsc)(2)] while the rest, display marginal cytogenetic and antitumour effects.
Περιγραφή
Λέξεις-κλειδιά
Anti-Bacterial Agents, Anti-Infective Agents/*chemical synthesis/chemistry/*pharmacology, Antifungal Agents/chemical synthesis/chemistry/pharmacology, Antineoplastic Agents/*chemical synthesis/chemistry/*pharmacology, Candida albicans/drug effects, Crystallography, X-Ray, Escherichia coli/drug effects, Magnetic Resonance Spectroscopy, Molecular Structure, Organoplatinum Compounds/*chemical synthesis/chemistry/*pharmacology, Spectrophotometry, Staphylococcus aureus/drug effects, Thiosemicarbazones/*chemical synthesis/chemistry/*pharmacology
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/11566327
http://ac.els-cdn.com/S0162013401002240/1-s2.0-S0162013401002240-main.pdf?_tid=abd3ff9ad741d693b60980f5b6ea3681&acdnat=1332846536_ab85441cd98f854a14ff38881b41a38c
http://ac.els-cdn.com/S0162013401002240/1-s2.0-S0162013401002240-main.pdf?_tid=abd3ff9ad741d693b60980f5b6ea3681&acdnat=1332846536_ab85441cd98f854a14ff38881b41a38c
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής