Statin therapy after first stroke reduces 10-year stroke recurrence and improves survival

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dc.contributor.authorMilionis, H. J.en
dc.contributor.authorGiannopoulos, S.en
dc.contributor.authorKosmidou, M.en
dc.contributor.authorPanoulas, V.en
dc.contributor.authorManios, E.en
dc.contributor.authorKyritsis, A. P.en
dc.contributor.authorElisaf, M. S.en
dc.contributor.authorVemmos, K.en
dc.date.accessioned2015-11-24T18:50:41Z
dc.date.available2015-11-24T18:50:41Z
dc.identifier.issn1526-632X-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/18127
dc.rightsDefault Licence-
dc.subjectAgeden
dc.subjectBrain Ischemia/*drug therapy/mortality/*prevention & controlen
dc.subjectCohort Studiesen
dc.subjectConfidence Intervalsen
dc.subjectFemaleen
dc.subjectFollow-Up Studiesen
dc.subjectForecastingen
dc.subjectHumansen
dc.subjectHydroxymethylglutaryl-CoA Reductase Inhibitors/*therapeutic useen
dc.subjectKaplan-Meier Estimateen
dc.subjectMaleen
dc.subjectMultivariate Analysisen
dc.subjectProportional Hazards Modelsen
dc.subjectRecurrence/prevention & controlen
dc.subjectRegistriesen
dc.subjectRegression Analysisen
dc.subjectRetrospective Studiesen
dc.subjectStroke/*drug therapy/mortality/*prevention & controlen
dc.subjectTreatment Outcomeen
dc.titleStatin therapy after first stroke reduces 10-year stroke recurrence and improves survivalen
heal.abstractOBJECTIVE: To determine whether statin therapy after hospital discharge affects ischemic stroke recurrence and long-term mortality in patients admitted for a first-ever occurrence of ischemic stroke. METHODS: This was a retrospective observational study involving linked hospitalization and death records. The cohort comprised a series of 794 consecutive, first-ever acute ischemic stroke patients from the Athenian Stroke Registry, admitted to the acute stroke unit and the general medicine and neurology ward of our institutions since January 1997 for whom there was available information covering a 10-year follow-up period. Cox proportional hazards model was used to identify risk factors for stroke recurrence and death. RESULTS: The recurrence rate was 16.3% among stroke patients not receiving a statin after hospital discharge compared with 7.5% among those who received statin therapy (p = 0.002). Cox regression analyses revealed only statin therapy postdischarge to be a significant independent predictor of stroke recurrence (adjusted hazard ratio [HR], 0.65, 95% confidence interval [CI] 0.39 to 0.97, p < 0.01). Similarly, patients receiving a statin had a significantly lower mortality during the 10-year period after the acute cerebrovascular event (adjusted HR, 0.43; 95% CI 0.29 to 0.61, p < 0.01). CONCLUSIONS: Prescribing statin therapy upon hospital discharge to patients with first-ever acute stroke lowers the risk of 10-year stroke recurrence and improves survival.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1212/WNL.0b013e3181a711cb-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/19470963-
heal.identifier.secondaryhttp://www.neurology.org/content/72/21/1816-
heal.journalNameNeurologyen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2009-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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