Meta-analysis of the association of beta2-adrenergic receptor polymorphisms with asthma phenotypes
| dc.contributor.author | Contopoulos-Ioannidis, D. G. | en |
| dc.contributor.author | Manoli, E. N. | en |
| dc.contributor.author | Ioannidis, J. P. | en |
| dc.date.accessioned | 2015-11-24T19:04:41Z | |
| dc.date.available | 2015-11-24T19:04:41Z | |
| dc.identifier.issn | 0091-6749 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/20088 | |
| dc.rights | Default Licence | - |
| dc.subject | Alleles | en |
| dc.subject | Asthma/*genetics | en |
| dc.subject | Case-Control Studies | en |
| dc.subject | Cohort Studies | en |
| dc.subject | Genetic Predisposition to Disease | en |
| dc.subject | Homozygote | en |
| dc.subject | Humans | en |
| dc.subject | Odds Ratio | en |
| dc.subject | Polymorphism, Genetic | en |
| dc.subject | Receptors, Adrenergic, beta-2/*genetics | en |
| dc.subject | Risk Factors | en |
| dc.title | Meta-analysis of the association of beta2-adrenergic receptor polymorphisms with asthma phenotypes | en |
| heal.abstract | BACKGROUND: Two common polymorphisms of the beta2-adrenergic receptor gene (Arg16Gly and Gln27Glu ) have been extensively studied for their possible association with asthma-related phenotypes, but the results of individual studies have been inconclusive. OBJECTIVE: We aimed to integrate quantitatively the available evidence on the association of the Arg16Gly and the Gln27Glu polymorphisms with asthma, nocturnal asthma, asthma severity, and bronchial hyperresponsiveness. METHODS: Meta-analysis of case-control and cohort studies using random effects models. RESULTS: A total of 28 studies were included in the meta-analysis. The summary estimates suggested that neither the Gly16 nor the Glu27 allele contributes to asthma susceptibility overall (odds ratio [OR], 1.01; 95% CI, 0.90-1.13; and OR, 0.95; 95% CI, 0.83-1.09, respectively) or to bronchial hyperresponsiveness (OR, 0.90; 95% CI, 0.77-1.05; and OR, 1.07; 95% CI, 0.94-1.22, respectively). There was a strong association of Gly16 with nocturnal asthma (OR, 2.20; 95% CI, 1.56-3.11) and a less strong association with severe or moderate rather than milder asthma (OR, 1.42; 95% CI, 1.04-1.94). No such effects were seen for the Glu27 allele (OR, 1.02; 95% CI, 0.74-1.40; and OR, 0.82; 95% CI, 0.59-1.14, respectively). Moreover, there was evidence that Gly16 homozygotes had a much higher risk for nocturnal asthma (OR, 5.15; 95% CI, 2.44-10.84) and asthma severity (OR, 2.84; 95% CI, 1.62-4.96) than the Arg16 homozygotes. CONCLUSION: The Gly16 allele of the beta2-adrenergic receptor gene predisposes to nocturnal asthma, and this may also explain the association with asthma severity. Neither polymorphism modulates the risk for bronchial hyperresponsiveness or mild asthma. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | 10.1016/j.jaci.2004.12.1119 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/15867853 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/S0091674905000114/1-s2.0-S0091674905000114-main.pdf?_tid=46205294f089b5a3d2f1c0c717f78d1d&acdnat=1333364338_4cb44f62b5a0260cb1fde943d0ba818e | - |
| heal.journalName | J Allergy Clin Immunol | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2005 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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