Promoter hypermethylation of the MEG3 (DLK1/MEG3) imprinted gene in multiple myeloma
| dc.contributor.author | Benetatos, L. | en |
| dc.contributor.author | Dasoula, A. | en |
| dc.contributor.author | Hatzimichael, E. | en |
| dc.contributor.author | Georgiou, I. | en |
| dc.contributor.author | Syrrou, M. | en |
| dc.contributor.author | Bourantas, K. L. | en |
| dc.date.accessioned | 2015-11-24T18:56:05Z | |
| dc.date.available | 2015-11-24T18:56:05Z | |
| dc.identifier.issn | 1557-9190 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/18982 | |
| dc.rights | Default Licence | - |
| dc.subject | Aged | en |
| dc.subject | Aged, 80 and over | en |
| dc.subject | *DNA Methylation | en |
| dc.subject | Female | en |
| dc.subject | *Genomic Imprinting | en |
| dc.subject | Humans | en |
| dc.subject | Immunoglobulins/blood/genetics | en |
| dc.subject | Male | en |
| dc.subject | Middle Aged | en |
| dc.subject | Multiple Myeloma/blood/*genetics | en |
| dc.subject | *Promoter Regions, Genetic | en |
| dc.subject | Prospective Studies | en |
| dc.subject | Proteins/*genetics/metabolism | en |
| dc.title | Promoter hypermethylation of the MEG3 (DLK1/MEG3) imprinted gene in multiple myeloma | en |
| heal.abstract | BACKGROUND: Methylation represents the most studied epigenetic modification and results in the silencing of genes involved in various processes such as differentiation and cell-cycle regulation. MEG3 represents an imprinted gene maternally expressed in humans that encodes a nontranslated product. In this survey, we studied the methylation status of the specific gene in multiple myeloma (MM). PATIENTS AND METHODS: Twenty-one patients with MM (17 with immunoglobulin [Ig] G, 3 with IgA, and 1 with IgM) were evaluated using methylation-specific polymerase chain reaction (after DNA bisulphite modification). RESULTS: Promoter hypermethylation was observed in 12 (57.14%) bone marrow samples and in 9 of 14 (64.28%) available peripheral blood samples. A correlation with disease stage was also observed and also with the disease subtype (IgG, 64.7%; IgA, 0; IgM, 100%). CONCLUSION: We conclude that promoter hypermethylation of the differentially methylated region of the MEG3 imprinted gene is observed in patients with MM. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | 10.3816/CLM.2008.n.021 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/18650181 | - |
| heal.identifier.secondary | http://cigjournals.metapress.com/content/l52q2717061r8469/fulltext.pdf | - |
| heal.journalName | Clin Lymphoma Myeloma | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2008 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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