Effect of CCR5-delta32 heterozygosity on the risk of perinatal HIV-1 infection: a meta-analysis

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dc.contributor.authorContopoulos-Ioannidis, D. G.en
dc.contributor.authorO'Brien, T. R.en
dc.contributor.authorGoedert, J. J.en
dc.contributor.authorRosenberg, P. S.en
dc.contributor.authorIoannidis, J. P.en
dc.date.accessioned2015-11-24T19:23:02Z
dc.date.available2015-11-24T19:23:02Z
dc.identifier.issn1525-4135-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/22232
dc.rightsDefault Licence-
dc.subjectContinental Population Groups/geneticsen
dc.subjectEurope/ethnologyen
dc.subjectFemaleen
dc.subjectHIV Infections/ethnology/*genetics/*transmissionen
dc.subjectHIV-1/physiologyen
dc.subject*Heterozygoteen
dc.subjectHomozygoteen
dc.subjectHumansen
dc.subjectInfant, Newbornen
dc.subject*Infectious Disease Transmission, Verticalen
dc.subjectMaleen
dc.subjectPolymorphism, Genetic/geneticsen
dc.subjectPregnancyen
dc.subjectReceptors, CCR5/*geneticsen
dc.subjectRisk Factorsen
dc.titleEffect of CCR5-delta32 heterozygosity on the risk of perinatal HIV-1 infection: a meta-analysisen
heal.abstractSeveral studies have investigated whether heterozygosity for a 32-basepair deletion in the CC chemokine receptor 5 gene (CCR5-Delta32 ) affects susceptibility to perinatal HIV-1 infection, but results have been inconclusive. We performed a meta-analysis of published data from 11 studies of HIV-1 perinatally exposed children who were genotyped for the CCR5-Delta32 polymorphism. The crude overall HIV-1 infection rates, by simple data pooling, were 20% (one of five) amongCCR5-Delta32 homozygote children, 39% (131 of 335) among CCR5-Delta32 heterozygote children, and 40% (1408 of 3526) among wild-type CCR5 homozygote children. Compared with wild-type homozygotes, the random effects risk ratio for heterozygotes was 1.04 (95% confidence interval [CI], 0.92-1.17) among all children (N = 3861) and 1.03 (95% CI, 0.90-1.17) among those of European descent (n = 2890). Results were similar when adjusted for the available data on the CCR2-641 polymorphism (n = 1542). The meta-analysis clarifies that perinatal infection is not significantly altered by heterozygosity for CCR5-Delta32 in the child.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/12514416-
heal.journalNameJ Acquir Immune Defic Syndren
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2003-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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