Immunization of patients with Sjogren's syndrome with pneumococcal polysaccharide vaccine: a randomized trial
| dc.contributor.author | Karsh, J. | en |
| dc.contributor.author | Pavlidis, N. | en |
| dc.contributor.author | Schiffman, G. | en |
| dc.contributor.author | Moutsopoulos, H. M. | en |
| dc.date.accessioned | 2015-11-24T19:12:04Z | |
| dc.date.available | 2015-11-24T19:12:04Z | |
| dc.identifier.issn | 0004-3591 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/21012 | |
| dc.rights | Default Licence | - |
| dc.subject | Adult | en |
| dc.subject | Aged | en |
| dc.subject | Antibodies, Bacterial/analysis | en |
| dc.subject | *Antibody Formation | en |
| dc.subject | Bacterial Vaccines/*immunology | en |
| dc.subject | Clinical Trials as Topic | en |
| dc.subject | Female | en |
| dc.subject | Humans | en |
| dc.subject | Immunization | en |
| dc.subject | Middle Aged | en |
| dc.subject | Polysaccharides, Bacterial/immunology | en |
| dc.subject | Sjogren's Syndrome/*immunology | en |
| dc.subject | Streptococcus pneumoniae/*immunology | en |
| dc.title | Immunization of patients with Sjogren's syndrome with pneumococcal polysaccharide vaccine: a randomized trial | en |
| heal.abstract | Thirty-two patients with Sjogren's syndrome were randomly selected to receive either multivalent pneumococcal polysaccharide vaccine or saline placebo in a double-blind study. Among placebo treated patients, levels of antipneumococcal antibodies remained constant. Immunized patients developed significant elevations of antibody concentrations against all 12 capsular serotypes measured. Levels fell, but persisted above baseline, for 8 of the serotypes 6 months after immunization. During the 6-month study no clinical or serologic evidence of disease exacerbation occurred in either group. We conclude that pneumococcal vaccine can be safely and successfully administered to patients with Sjogren's syndrome. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/7004446 | - |
| heal.identifier.secondary | http://onlinelibrary.wiley.com/store/10.1002/art.1780231111/asset/1780231111_ftp.pdf?v=1&t=h0nhxw2k&s=cc571cbe33200ad740dae1806a96d3860ee25061 | - |
| heal.journalName | Arthritis Rheum | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 1980 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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