Major histocompatibility complex (MHC)-I and MHC-II expression in Hodgkin's disease in relation to the presence of Epstein-Barr Virus (EBV)

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dc.contributor.authorTzardi, M.en
dc.contributor.authorKouvidou, C.en
dc.contributor.authorPapakonstantinou, E.en
dc.contributor.authorDatseris, G.en
dc.contributor.authorDarivianaki, K.en
dc.contributor.authorKaridi, E.en
dc.contributor.authorEliopoulos, G.en
dc.contributor.authorDelidis, G.en
dc.contributor.authorRontogianni, D.en
dc.contributor.authorKanavaros, P.en
dc.date.accessioned2015-11-24T19:05:44Z
dc.date.available2015-11-24T19:05:44Z
dc.identifier.issn0250-7005-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/20234
dc.rightsDefault Licence-
dc.subject*Herpesvirus 4, Humanen
dc.subjectHistocompatibility Antigens Class I/*analysisen
dc.subjectHistocompatibility Antigens Class II/*analysisen
dc.subjectHodgkin Disease/*immunology/*virologyen
dc.subjectHumansen
dc.subjectIn Situ Hybridizationen
dc.subjectRNA, Messenger/analysisen
dc.subjectRNA, Viral/analysisen
dc.subjectTumor Virus Infections/*immunologyen
dc.subjectbeta 2-Microglobulin/*analysisen
dc.titleMajor histocompatibility complex (MHC)-I and MHC-II expression in Hodgkin's disease in relation to the presence of Epstein-Barr Virus (EBV)en
heal.abstractWe have investigated the immunohistochemical expression of beta2-microglobulin and HLA-DR proteins in Hodgkin's disease (HD) in relation to the expression of the EBV-encoded EBER1-2 mRNAs and the LMP-1 protein. beta2-microglobulin is expressed in association with MHC-I molecules on most nucleated cells and HLA-DR belongs to the MHC-II molecules which are expressed mostly on antigen-presenting cells. Formalin-fixed paraffin embedded tissue from 39 cases of lymphonodal HD were stained by immunohistochemistry for beta2-microglobulin, HLA-DR and LMP-1 proteins and by RNA in situ hybridization for EBER1-2 mRNAs. beta2-microglobulin positive staining was found in Reed-Sternberg and Hodgkin cells (HRS cells) in 18/39 cases of HD. HLA-DR positive staining was found in HRS cells in all cases of HD. EBER1-2 transcripts and LMP-1 protein were detected in HRS cells in 16/39 cases of HD. No correlation as found between the presence of EBER 1-2 transcripts or the LMP-1 protein and the detection of beta2-microglobulin and HLA-DR proteins in HD. Thus, EBV does not seem to use downregulation of MHC-I to avoid the T-cell cytotoxic immune response in HD. In addition, EBV does not seem to be the only factor responsible for the HLA-DR expression in HRS cells of HD, although it could participate in the induction of the expression of HLA-DR molecule in the EBV positive cases of HD.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/8687136-
heal.journalNameAnticancer Resen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1996-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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