The effect of indomethacin, diclofenac and flurbiprofen on the maintenance of mydriasis during extracapsular cataract extraction

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dc.contributor.authorPsilas, K.en
dc.contributor.authorKalogeropoulos, C.en
dc.contributor.authorLoucatzicos, E.en
dc.contributor.authorAsproudis, I.en
dc.contributor.authorPetroutsos, G.en
dc.date.accessioned2015-11-24T19:41:59Z
dc.date.available2015-11-24T19:41:59Z
dc.identifier.issn0012-4486-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/24565
dc.rightsDefault Licence-
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectCataract Extraction/*adverse effectsen
dc.subjectDiclofenac/administration & dosageen
dc.subjectFlurbiprofen/administration & dosageen
dc.subjectHumansen
dc.subjectIndomethacin/administration & dosageen
dc.subjectIntraoperative Complications/etiology/*prevention & controlen
dc.subjectLens Capsule, Crystalline/*surgeryen
dc.subjectMiddle Ageden
dc.subjectMiosis/etiology/*prevention & controlen
dc.subjectOphthalmic Solutionsen
dc.subjectPremedicationen
dc.subjectPupil/*drug effectsen
dc.subjectTreatment Outcomeen
dc.titleThe effect of indomethacin, diclofenac and flurbiprofen on the maintenance of mydriasis during extracapsular cataract extractionen
heal.abstractSurgically induced miosis (SIM) frequently occurs during extracapsular cataract extraction (ECCE). A randomized clinical trial was performed to evaluate the effect of 3 nonsteroidal antiinflammatory drugs Indomethacin 1%, Diclofenac 0.1% and Flurbiprofen 0.03%, administered topically before ECCE, on the maintenance of mydriasis during surgery. The patients were grouped based on the type of NSAID given preoperatively in addition to the standard mydriatic agents: 46 patients in group A (Indomethacin), 40 patients in B (Diclofenac), 44 patients in C (Flurbiprofen) and 34 patients formed control group D (no NSAID was instilled). Horizontal pupillary diameter measurements were taken, using a caliper, immediately prior to surgery (step 0), after capsulotomy (step I), after expression of the lens nucleus (step II) and after irrigation-aspiration of the cortical remnants (step III). Differences in pupillary diameter between step 0 and the different surgical steps were used as indices of pupillary constrictions observed in the 4 groups. A significantly less pupillary constriction was found in groups A and C than in D between steps 0 and II (p = 0.01) and in groups A and C than in B and D between steps 0 and III (p = 0.001). Our results show that Indomethacin 1% and Flurbiprofen 0.03%, compared to Diclofenac 0.1% and no NSAID regime, are significantly more effective in maintaining mydriasis during cataract surgery.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/1483371-
heal.identifier.secondaryhttp://www.springerlink.com/content/p2p328p214343061/fulltext.pdf-
heal.journalNameDoc Ophthalmolen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1992-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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