Rheumatoid arthritis in Greek and British patients. A comparative clinical, radiologic, and serologic study
Φόρτωση...
Ημερομηνία
Συγγραφείς
Drosos, A. A.
Lanchbury, J. S.
Panayi, G. S.
Moutsopoulos, H. M.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Arthritis Rheum
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
OBJECTIVE: To compare the clinical, radiologic, and serologic expression of rheumatoid arthritis (RA) in 2 different populations. METHODS: Standard protocols and assessment criteria were used in this study of 108 Greek and 107 British patients with RA. RESULTS: British patients had more severe articular involvement than did Greeks, as judged by the duration of morning stiffness (P less than 0.005), grip strength (P less than 0.0001), and the numbers of swollen (P less than 0.001) and tender (P less than 0.0001) joints. The British RA patients also had more severe joint damage on radiologic examination, as evidenced by Steinbrocker stage III (P less than 0.005) and IV (P less than 0.025) disease and had more extraarticular manifestations (P less than 0.0001), including rheumatoid nodules (P less than 0.0001) and Raynaud's phenomenon (P less than 0.05). Greek RA patients, however, more frequently presented with sicca manifestations (P less than 0.001) and serum antibodies to Ro/SS-A (P less than 0.025). Furthermore, Ro/SS-A antibodies were associated with a high incidence of side effects to D-penicillamine only in the Greeks. CONCLUSION: Genetic and environmental factors may be responsible for these striking differences in disease expression between these 2 European populations with RA.
Περιγραφή
Λέξεις-κλειδιά
Antibodies, Antinuclear/analysis, Arthritis, Rheumatoid/*ethnology/immunology/radiography, Female, Great Britain, Greece, Hand/radiography, Humans, Male
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/1622412
http://onlinelibrary.wiley.com/store/10.1002/art.1780350705/asset/1780350705_ftp.pdf?v=1&t=h0m1rrm4&s=70d4811a6cdf1771baff218fa14c1d053c032992
http://onlinelibrary.wiley.com/store/10.1002/art.1780350705/asset/1780350705_ftp.pdf?v=1&t=h0m1rrm4&s=70d4811a6cdf1771baff218fa14c1d053c032992
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής