Biological studies of new organotin(IV) complexes of thioamide ligands

Απλή σελίδα τεκμηρίου
dc.contributor.authorXanthopoulou, M. N.en
dc.contributor.authorHadjikakou, S. K.en
dc.contributor.authorHadjiliadis, N.en
dc.contributor.authorMilaeva, E. R.en
dc.contributor.authorGracheva, J. A.en
dc.contributor.authorTyurin, V. Y.en
dc.contributor.authorKourkoumelis, N.en
dc.contributor.authorChristoforidis, K. C.en
dc.contributor.authorMetsios, A. K.en
dc.contributor.authorKarkabounas, S.en
dc.contributor.authorCharalabopoulos, K.en
dc.date.accessioned2015-11-24T16:53:10Z
dc.date.available2015-11-24T16:53:10Z
dc.identifier.issn0223-5234-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/9981
dc.rightsDefault Licence-
dc.subjectbioinorganic chemistryen
dc.subjectorganotin(iv) complexesen
dc.subjects ligands-heterocyclic thioamidesen
dc.subjectcatalytic peroxidation of fatty acidsen
dc.subjectcytotoxic actionen
dc.subjectstructural-characterizationen
dc.subjectplatinum compoundsen
dc.subjectlinoleic-aciden
dc.subjectbinding-siteen
dc.subjectderivativesen
dc.subject5-chloro-2-mercaptobenzothiazoleen
dc.subjecttriethyltinen
dc.subject2-mercaptobenzothiazoleen
dc.subjectlipoxygenaseen
dc.subjectperoxidationen
dc.titleBiological studies of new organotin(IV) complexes of thioamide ligandsen
heal.abstractNew organotin(IV) complexes with heterocyclic thioamides 2-mercapto-benzothiazole (Hmbzt), 5-chloro-2-mercapto-benzottliazole (Hcmbzt) and 2-mercapto-benzoxazole (Hmbzo) of formulae [(C(6)H(5))(3)Sn(mbzt)] (1), [(C(6)H(5))(3)Sn(cmbzt)] (3) and [(C(6)H(5))(2)Sn(cmbzt)(2)] (4), together with the already known [(C(6)H(5))(3)Sn(mbzo)] (2), [(n-C(4)H(9))(2)Sn(cmbZt)(2)] (5) and [(CH(3))(2)Sn(cmbzt)(2)] (6) were used to study their influence on the peroxidation of oleic acid. The influence of complexes (3)-(6) upon peroxidation of oleic acid showed that the formation of reactive radicals caused the initiation of the chain radical oxidation of the substrate. The influence of complexes (1)-(6) upon the catalytic peroxidation of linoleic acid by the enzyme lipoxygenase (LOX) was also studied and compared to those of cisplatin. Compounds (1)-(6) were finally tested for in vitro cytotoxicity against leiomyosarcoma cells. (c) 2007 Elsevier Masson SAS. All rights reserved.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primaryDOI 10.1016/j.ejmech.2007.03.028-
heal.identifier.secondary<Go to ISI>://000254031400011-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0223523407001614/1-s2.0-S0223523407001614-main.pdf?_tid=d6e4d31afbc398a09721d1bac770dc2d&acdnat=1333030315_ac546532df6fa05fba711ce1cb5a2776-
heal.journalNameEur J Med Chemen
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2008-
heal.publisherElsevieren
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

Αρχεία

Φάκελος/Πακέτο αδειών

Προβολή: 1 - 1 of 1
Μικρογραφία εικόνας
Ονομα:
license.txt
Μέγεθος:
1.74 KB
Μορφότυπο:
Item-specific license agreed upon to submission
Περιγραφή:
Κατεβάστε

Συλλογές

Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά). ΧΗΜ