Metabolic syndrome and cerebral vasomotor reactivity
Φόρτωση...
Ημερομηνία
Συγγραφείς
Giannopoulos, S.
Boden-Albala, B.
Choi, J. H.
Carrera, E.
Doyle, M.
Perez, T.
Marshall, R. S.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Eur J Neurol
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
BACKGROUND AND PURPOSE: Metabolic syndrome has been proposed as a risk factor for stroke and transient ischaemic attack. One pathophysiological mechanism could be impairment of endothelial function. Thus, we hypothesized that cerebral vasomotor reactivity would be decreased in patients with metabolic syndrome, compared to patients without metabolic syndrome. METHODS: In this retrospective analysis, 83 consecutive patients (aged 59.19 +/- 15.98; 33 women) underwent Doppler examination for carotid artery disease including bi-hemispherical vasomotor reactivity assessment using transcranial Doppler monitoring. Vasomotor reactivity data were analyzed from the hemisphere with no or low-grade carotid stenosis (<40%). Cerebral vasomotor reactivity was calculated as percent increase in mean flow velocity per mmHg pCO(2) during 2 min of 5% CO(2) inhalation delivered by anesthesia mask (normal if >/= 2%/mmHg). Univariate and multivariable linear regression models were used to determine factors, including metabolic syndrome, that were independently associated with pathologic vasomotor reactivity. RESULTS: After adjusting for the presence of contralateral carotid stenosis and ipsilateral stroke in the multivariable model, metabolic syndrome was independently associated with lower vasomotor reactivity values (2.27 +/- 1.24% vs. 2.68 +/- 1.37; ss = -0.258, P = 0.033). In this model, there was no association of cerebral vasomotor reactivity with age, gender, race, cardiac disease, current statin therapy, or small vessel disease. CONCLUSIONS: Our findings suggest that impaired cerebral vasomotor reactivity may be a mediator of stroke in patients with metabolic syndrome, a syndrome affecting a significant and growing proportion of the population. A prospective longitudinal study is warranted to study the cerebral haemodynamic effect of metabolic syndrome.
Περιγραφή
Λέξεις-κλειδιά
Brain/*blood supply, Cerebrovascular Disorders/complications/*physiopathology, Female, Humans, Male, Metabolic Syndrome X/complications/*physiopathology, Middle Aged, Regional Blood Flow/physiology, Ultrasonography, Doppler, Transcranial/methods, Vasomotor System/*physiopathology
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/20500212
http://onlinelibrary.wiley.com/store/10.1111/j.1468-1331.2010.03087.x/asset/j.1468-1331.2010.03087.x.pdf?v=1&t=h0akxikg&s=9be2a2770748b843ec7c7b94b21981eb0441aa89
http://onlinelibrary.wiley.com/store/10.1111/j.1468-1331.2010.03087.x/asset/j.1468-1331.2010.03087.x.pdf?v=1&t=h0akxikg&s=9be2a2770748b843ec7c7b94b21981eb0441aa89
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής