Studies on the enzymatic synthesis of lipophilic derivatives of natural antioxidants
| dc.contributor.author | Stamatis, H. | en |
| dc.contributor.author | Sereti, V. | en |
| dc.contributor.author | Kolisis, F. | en |
| dc.date.accessioned | 2015-11-24T16:32:15Z | |
| dc.date.available | 2015-11-24T16:32:15Z | |
| dc.identifier.issn | 0003-021X | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/7534 | |
| dc.rights | Default Licence | - |
| dc.subject | Chemistry and Materials Science | en |
| dc.title | Studies on the enzymatic synthesis of lipophilic derivatives of natural antioxidants | en |
| heal.abstract | The esterification of some natural antioxidants such as cinnamic acid derivatives and ascorbic acid in non-aqueous media, catalyzed by immobilized lipases from Candida antarctica and Rhizomucor miehei , was investigated. The alcohol chain length affected the rate of esterification of cinnamic acids by both lipases. Higher reaction rates were observed when the esterification was carried out with medium- or long-chain alcohols. The rate also depended on aromatic acid structure. The reactivity of the carboxylic function of the cinnamic acids was affected by electron-donating substituents in the aromatic ring. Higher yields were observed for the esterification of p -hydroxyphenylacetic acid (97%) catalyzed by C. antarctica lipase and for the esterification of cinnamic acid (59%) catalyzed by R. miehei lipase. Candida antarctica lipase was more suitable for producing ascorbic acid fatty esters, catalyzing with a relatively high yield (up to 65% within 24 h) the regioselective esterification of ascorbic acid with various fatty acids in 2-methyl-2-propanol. The reaction rate and yield depended on the fatty acid chain length and on the molar ratio of reactants. All ascorbic acid fatty esters produced by this procedure exhibited a significant antioxidant activity in a micellar substrate composed of linoleic acid. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | 10.1007/s11746-999-0193-1 | - |
| heal.identifier.secondary | http://dx.doi.org/10.1007/s11746-999-0193-1 | - |
| heal.journalName | Journal of the American Oil Chemists' Society | en |
| heal.journalType | peer reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 1999 | - |
| heal.publisher | Springer Berlin / Heidelberg | en |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών και Τεχνολογιών. Τμήμα Βιολογικών Εφαρμογών και Τεχνολογιών | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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