Statin therapy is associated with reduced total and cardiovascular mortality after coronary artery bypass grafting surgery

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dc.contributor.authorPapathanasiou, A.en
dc.contributor.authorToumpoulis, I. K.en
dc.contributor.authorMilionis, H. J.en
dc.contributor.authorKalantzi, K.en
dc.contributor.authorKatsouras, C. S.en
dc.contributor.authorGoudevenos, J.en
dc.date.accessioned2015-11-24T18:50:40Z
dc.date.available2015-11-24T18:50:40Z
dc.identifier.issn1473-5830-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/18126
dc.rightsDefault Licence-
dc.subjectAgeden
dc.subjectCardiovascular Diseases/etiology/mortality/*prevention & controlen
dc.subjectCoronary Artery Bypass/adverse effects/*mortalityen
dc.subjectCoronary Artery Disease/*drug therapy/mortality/*surgeryen
dc.subjectFemaleen
dc.subjectGreece/epidemiologyen
dc.subjectHumansen
dc.subjectHydroxymethylglutaryl-CoA Reductase Inhibitors/*therapeutic useen
dc.subjectKaplan-Meier Estimateen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectPostoperative Careen
dc.subjectProportional Hazards Modelsen
dc.subjectRetrospective Studiesen
dc.subjectRisk Assessmenten
dc.subjectTime Factorsen
dc.subjectTreatment Outcomeen
dc.titleStatin therapy is associated with reduced total and cardiovascular mortality after coronary artery bypass grafting surgeryen
heal.abstractOBJECTIVE: In an observational study, we evaluated the association between postoperative statin therapy and long-term mortality among patients undergoing a first-ever coronary artery bypass grafting (CABG) surgery. METHODS: In an outpatient clinic setting, we assessed 1869 consecutive patients (age 58.7+/-9.6 years; 1657 men), who survived the 1st month after a first-ever CABG, within a 17-year period. Cox proportional hazard analysis was used to calculate the adjusted hazard ratios (adjusting for age, smoking, the presence of hypertension, diabetes mellitus, lipid profile at the time of the procedure, vessel disease, number and kind of grafts used, and concomitant treatment) for patients receiving statin treatment during follow-up and adjusted Kaplan-Meier survival curves were constructed. RESULTS: During a 9345 patient-years follow-up, 48% of the patients were on a statin. In a total of 222 deaths, 80.6% were because of cardiovascular causes. Total and cardiovascular mortality were significantly reduced in patients receiving statin therapy [adjusted hazard ratio, 0.48 (95% confidence interval, 0.28-0.82); P=0.007), and 0.43 (95% confidence interval, 0.23-0.80); P=0.007, respectively]. The estimated 16-year Kaplan-Meier survival curves diverged at 2 years and thereafter. CONCLUSION: Taking into account the potential limitations of observational data, statin treatment postoperatively is associated with a 50% reduction in total and cardiovascular mortality in patients undergoing a first-ever CABG.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1097/MCA.0b013e3283142607-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/19005297-
heal.journalNameCoron Artery Disen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2008-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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