Effect of diet on lignans and isoflavonoid phytoestrogens in chimpanzees
Φόρτωση...
Ημερομηνία
Συγγραφείς
Musey, P. I.
Adlercreutz, H.
Gould, K. G.
Collins, D. C.
Fotsis, T.
Bannwart, C.
Makela, T.
Wahala, K.
Brunow, G.
Hase, T.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Life Sci
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Diphenolic compounds belonging to the classes of lignans and isoflavonoids have been identified in urine of man and animals, including the chimpanzee. Some of these compounds, formed by intestinal bacteria from plant lignans and phytoestrogens, have been shown in animal studies to exhibit biological activities that suggest they could function as cancer-protective compounds. The effect of diet on urinary excretion of these compounds in the adult male chimpanzee has been studied. It was found that the chimpanzees consuming their regular food excreted large amounts of the isoflavonoid phytoestrogens, equol (mean +/- SE) (127.5 +/- 34.0 nmol/mg cr.) and daidzein (20.7 +/- 9.0 nmol/mg cr.) and the lignan, enterolactone (14.1 + 3.5 nmol/mg cr.). Small amounts of the lignan, enterodiol, (0.4 +/- 0.2 nmol/mg cr.) were also excreted. On all other four test diets (high protein, high carbohydrate, high vegetable, and high fat), the excretion was less, particularly on a high fat diet where the excretion of all diphenolic compounds was reduced by more than 90% to a level observed in omnivorous human subjects or women with breast cancer. These results suggest that diet profoundly influences the excretion of both animal lignans and phytoestrogens in urine. Because non-human primates are particularly resistant to mammary and genital carcinoma on estrogen treatment, the present data suggest that the very high levels of phytoestrogens and lignans as found during exposure to the regular diet may partially account for why these primates are so resistant to hormonal manipulations to induce cancer.
Περιγραφή
Λέξεις-κλειδιά
Animals, Chromatography, Gas, Chromatography, High Pressure Liquid, *Diet, Estrogens, Non-Steroidal/*metabolism/urine, *Isoflavones, Lignans/*metabolism/urine, Male, Pan troglodytes, Phytoestrogens, Plant Preparations, Plants/metabolism
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/7637537
http://ac.els-cdn.com/002432059500317Y/1-s2.0-002432059500317Y-main.pdf?_tid=4b517aa9b82e031f86e1f399e895b62d&acdnat=1332753193_d251f5bafa879036d415648add7bc866
http://ac.els-cdn.com/002432059500317Y/1-s2.0-002432059500317Y-main.pdf?_tid=4b517aa9b82e031f86e1f399e895b62d&acdnat=1332753193_d251f5bafa879036d415648add7bc866
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής