Prevention of UVB-induced immunosuppression in mice by the green tea polyphenol (-)-epigallocatechin-3-gallate may be associated with alterations in IL-10 and IL-12 production

Απλή σελίδα τεκμηρίου
dc.contributor.authorKatiyar, S. K.en
dc.contributor.authorChalla, A.en
dc.contributor.authorMcCormick, T. S.en
dc.contributor.authorCooper, K. D.en
dc.contributor.authorMukhtar, H.en
dc.date.accessioned2015-11-24T18:56:39Z
dc.date.available2015-11-24T18:56:39Z
dc.identifier.issn0143-3334-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/19075
dc.rightsDefault Licence-
dc.subjectAdministration, Topicalen
dc.subjectAnimalsen
dc.subjectAnticarcinogenic Agents/administration & dosage/*pharmacologyen
dc.subjectCatechin/administration & dosage/*analogs & derivatives/pharmacologyen
dc.subjectFemaleen
dc.subjectImmune System/*drug effects/radiation effectsen
dc.subjectInterleukin-10/*biosynthesisen
dc.subjectInterleukin-12/*biosynthesisen
dc.subjectMiceen
dc.subjectMice, Inbred C3Hen
dc.subjectTea/*chemistryen
dc.subjectUltraviolet Raysen
dc.titlePrevention of UVB-induced immunosuppression in mice by the green tea polyphenol (-)-epigallocatechin-3-gallate may be associated with alterations in IL-10 and IL-12 productionen
heal.abstractUV exposure of the skin, particularly UVB (290-320 nm), causes adverse biological effects, including alterations in cutaneous immune cells, photoaging and photocarcinogenesis. Several studies have shown that polyphenolic compounds isolated from green tea afford protection against UVB-induced inflammatory responses and photocarcinogenesis in murine models. In this study we show that topical application of (-)-epigallocatechin-3-gallate (EGCG) (3 mg/mouse), a major polyphenolic component of green tea, before a single low dose UVB exposure (72 mJ/cm(2)) to C3H/HeN mice prevented UVB-induced inhibition of the contact hypersensitivity response and tolerance induction to the contact sensitizer 2, 4-dinitrofluorobenzene. Topical application of EGCG before UVB exposure reduced the number of CD11b+ monocytes/macrophages and neutrophils infiltrating into skin inflammatory lesions, which are considered to be responsible for creating the UV-induced immunosuppressive state. In addition, application of EGCG before UVB exposure decreased UVB-induced production of the immunomodulatory cytokine interleukin (IL)-10 in skin as well as in draining lymph nodes (DLN), whereas production of IL-12, which is considered to be a mediator and adjuvant for induction of contact sensitivity, was found to be markedly increased in DLN when compared with UVB alone-exposed mice. Taken together, our data demonstrate that EGCG protects against UVB-induced immunosuppression and tolerance induction by: (i) blocking UVB-induced infiltration of CD11b+ cells into the skin; (ii) reducing IL-10 production in skin as well as in DLN; (iii) markedly increasing IL-12 production in DLN. Protection against UVB-induced immunosuppression by EGCG may be associated with protection against UVB-induced photocarcinogenesis.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/10545414-
heal.identifier.secondaryhttp://carcin.oxfordjournals.org/content/20/11/2117.full.pdf-
heal.journalNameCarcinogenesisen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1999-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

Αρχεία

Φάκελος/Πακέτο αδειών

Προβολή: 1 - 1 of 1
Μικρογραφία εικόνας
Ονομα:
license.txt
Μέγεθος:
1.74 KB
Μορφότυπο:
Item-specific license agreed upon to submission
Περιγραφή:
Κατεβάστε

Συλλογές

Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ