Combined carcinoid-adenocarcinoma tumour of the anal canal
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Date
Authors
Anagnostopoulos, G. K.
Arvanitidis, D.
Sakorafas, G.
Pavlakis, G.
Kolilekas, L.
Arkoumani, E.
Stefanou, D.
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Abstract
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peer-reviewed
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Scand J Gastroenterol
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Description
The concurrence of carcinoid admixed with adenocarcinoma in the gastrointestinal tract is an unusual phenomenon that has been reported in the oesophagus, stomach, small intestine, appendix, colon and rectum. These mixed or 'composite' tumours seem to be derived from a multipotential stem cell capable of bidirectional differentiation and have a worse prognosis than ordinary adenocarcinoma. Chromogranin-A staining has increased the diagnostic yield for detecting these tumours and provides information for perioperative management and long-term prognosis. We describe a patient who presented to our department due to painful defecation. Sigmoidoscopy demonstrated a mass in the anal canal. Histology revealed that the tumour was a mixed carcinoid-adenocarcinoma neoplasm. To our knowledge, this is the first report in the English literature of a composite tumour of the anal canal.
Description
Keywords
Adenocarcinoma/*pathology, Aged, Anal Canal/pathology, Anus Neoplasms/*pathology, Carcinoid Tumor/*pathology, Fatal Outcome, Humans, Neoplasms, Multiple Primary/*pathology, Sigmoidoscopy/methods
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Citation
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http://www.ncbi.nlm.nih.gov/pubmed/15000285
http://informahealthcare.com/doi/pdfplus/10.1080/00365520310007125
http://informahealthcare.com/doi/pdfplus/10.1080/00365520310007125
Language
en
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Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής