CENP-B specific anti-centromere autoantibodies heralding small-cell lung cancer. A case study and review of the literature

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dc.contributor.authorBriasoulis, E.en
dc.contributor.authorKamposioras, K.en
dc.contributor.authorTzovaras, V.en
dc.contributor.authorPafitanis, G.en
dc.contributor.authorKostoula, A.en
dc.contributor.authorMavridis, A.en
dc.contributor.authorPavlidis, N.en
dc.date.accessioned2015-11-24T19:31:14Z
dc.date.available2015-11-24T19:31:14Z
dc.identifier.issn0169-5002-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/23233
dc.rightsDefault Licence-
dc.subjectAntibodies, Antinuclear/*blooden
dc.subjectAntineoplastic Combined Chemotherapy Protocols/therapeutic useen
dc.subjectAutoantigens/immunologyen
dc.subjectCarcinoma, Small Cell/*blood/immunology/therapyen
dc.subjectCentromere Protein B/*immunologyen
dc.subjectCombined Modality Therapyen
dc.subjectFemaleen
dc.subjectFluorescent Antibody Techniqueen
dc.subjectHumansen
dc.subjectImmunoblottingen
dc.subjectLung Neoplasms/*blood/immunology/therapyen
dc.subjectMiddle Ageden
dc.subjectRadiotherapyen
dc.subjectSmokingen
dc.subjectSuperior Vena Cava Syndrome/complicationsen
dc.titleCENP-B specific anti-centromere autoantibodies heralding small-cell lung cancer. A case study and review of the literatureen
heal.abstractWe report on a small-cell lung cancer case that was heralded by the presence of CENP-B specific anti-centromere autoantibodies (ACA) detected well before the diagnosis of cancer. The patient received chemotherapy plus radiotherapy, which resulted in complete remission of the tumor. Serum ACA levels were zeroed at the time of radiological documentation of tumor response and remained undetected at serial follow-up assessments until they rose again along with documentation of tumor recurrence which occurred 12 months later. We review in brief published research and discuss anti-centromere autoantibodies as potential biomarkers in small-cell lung cancer, a highly proliferative tumor which lacks sensitive serum markers.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1016/j.lungcan.2007.09.014-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/17980453-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0169500207005569/1-s2.0-S0169500207005569-main.pdf?_tid=7ccadd5de2cb03305ca79b59c64710f2&acdnat=1333702146_925818e478461bcd4649d44cdac1a826-
heal.journalNameLung Canceren
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2008-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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