Effect of hypolipidemic drugs on lipoprotein-associated platelet activating factor acetylhydrolase - Implication for atherosclerosis
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Ημερομηνία
Συγγραφείς
Eisaf, M.
Tselepis, A. D.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Biochem Pharmacol
Όνομα βιβλίου
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Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Human plasma platelet activating factor acetylhydrolase (PAF-AH) is an enzyme associated mainly with the apolipoprotein B (apoB)containing lipoproteins and primarily with low-density lipoprotein (LDL). A small proportion of enzyme activity is also associated with high-density lipoprotein (HDL). PAF-AH activity is essential for the metabolism of PAF and oxidized phospholipids, i.e. bioactive lipids that are involved in the pathophysiology of atherosclerosis. Thus, PAF-AH may play a significant role in atherogenesis. Accumulating data indicate that PAF-AH associated with HDL particles plays a predominantly antiatherogenic role. By contrast, the role of LDL-associated PAF-AH remains controversial. Dyslipidemia induces a significant increase in total plasma PAF-AH activity and alters the enzyme distribution between proatherogenic apoB- and antiatherogenic apo AI-containing lipoproteins by increasing the PAF-AH activity associated with apoB-containing lipoproteins. The decreased rate of LDL removal from the circulation and the abnormal catabolism of triglyceride-rich lipoproteins play important roles in these abnormalities. Atorvastatin or fenofibrate therapy can restore, at least partially, the dyslipidemia-induced alterations in plasma PAF-AH by increasing the ratio of HDL-PAF-AH to plasma PAF-AH (or to LDL-cholesterol) levels, which may represent an important antiatherogenic effect of these hypolipidemic drugs. (C) 2003 Elsevier Inc. All rights reserved.
Περιγραφή
Λέξεις-κλειδιά
atherosclerosis, dyslipidemia, lipoproteins, paf-acetylhydrolase, atorvastatin, fenofibrate, low-density-lipoprotein, human-plasma, paf-ah, disease, ldl, hdl, hypercholesterolemia, metabolism, enzyme, risk
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Σύνδεσμος
<Go to ISI>://000186847300001
http://ac.els-cdn.com/S0006295203005598/1-s2.0-S0006295203005598-main.pdf?_tid=b0967c297efdd9a5dc460807a4421110&acdnat=1333111080_92805e71abf41d0f95f3a7e1b3774a9d
http://ac.els-cdn.com/S0006295203005598/1-s2.0-S0006295203005598-main.pdf?_tid=b0967c297efdd9a5dc460807a4421110&acdnat=1333111080_92805e71abf41d0f95f3a7e1b3774a9d
Γλώσσα
en
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Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας