Role of the Fcgamma receptor IIa polymorphism in susceptibility to systemic lupus erythematosus and lupus nephritis: a meta-analysis
| dc.contributor.author | Karassa, F. B. | en |
| dc.contributor.author | Trikalinos, T. A. | en |
| dc.contributor.author | Ioannidis, J. P. | en |
| dc.date.accessioned | 2015-11-24T18:53:08Z | |
| dc.date.available | 2015-11-24T18:53:08Z | |
| dc.identifier.issn | 0004-3591 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/18503 | |
| dc.rights | Default Licence | - |
| dc.subject | Antigens, CD/*genetics | en |
| dc.subject | Genetic Predisposition to Disease | en |
| dc.subject | Humans | en |
| dc.subject | Lupus Nephritis/*genetics | en |
| dc.subject | *Polymorphism, Genetic | en |
| dc.subject | Receptors, IgG/*genetics | en |
| dc.title | Role of the Fcgamma receptor IIa polymorphism in susceptibility to systemic lupus erythematosus and lupus nephritis: a meta-analysis | en |
| heal.abstract | OBJECTIVE: To assess the impact of the Fcgamma receptor type IIa (FcgammaRIIa)-R/H131 polymorphism on the risk for systemic lupus erythematosus (SLE) and development of lupus nephritis. METHODS: A meta-analysis was performed based on the Medline and Embase databases (last retrieval August 2001), assessment of bibliographies of pertinent articles, and additional data gathered after contact with primary investigators. RESULTS: A total of 25 comparisons from 17 studies involving R/H131 genotyping of 1,405 patients with lupus nephritis, 1,709 SLE patients without nephritis, and 2,580 non-SLE controls were included. No association between RR genotype and risk of lupus nephritis relative to both other genotypes (odds ratio [OR] 1.05, 95% confidence interval [95% CI] 0.88-1.27) was demonstrated in the total meta-analysis or in any racial subgroup. The RR genotype was more frequent in SLE patients as a whole (OR 1.30, 95% CI 1.10-1.52) and in SLE patients without nephritis (OR 1.27, 95% CI 1.04-1.55) compared with disease-free controls. A potential dose-response relation between the R131 allele and the risk of SLE was also identified, with an OR of 1.23 for RR versus RH (95% CI 1.03-1.46). The OR was 1.55 for RR versus HH (95% CI 1.21-1.98). There was no significant heterogeneity between racial subgroups. The population-attributable fractions of SLE cases due to the FcgammaRIIa-R131 allele were 13%, 40%, and 24% in subjects of European, African, and Asian descent, respectively. CONCLUSION: The FcgammaRIIa-R/H131 polymorphism represents a significant risk factor for SLE but has no clear effect on susceptibility for lupus nephritis. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | 10.1002/art.10306 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/12115187 | - |
| heal.identifier.secondary | http://onlinelibrary.wiley.com/store/10.1002/art.10306/asset/10306_ftp.pdf?v=1&t=h0jepoy8&s=7d9b801c74b7ee7ef99df331a02920c1f63e2b61 | - |
| heal.journalName | Arthritis Rheum | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2002 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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