Organotin(IV) derivatives of L-cysteine and their in vitro anti-tumor properties

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dc.contributor.authorChasapis, C. T.en
dc.contributor.authorHadjikakou, S. K.en
dc.contributor.authorGaroufis, A.en
dc.contributor.authorHadjiliadis, N.en
dc.contributor.authorBakas, T.en
dc.contributor.authorKubicki, M.en
dc.contributor.authorMing, Y.en
dc.date.accessioned2015-11-24T16:43:38Z
dc.date.available2015-11-24T16:43:38Z
dc.identifier.issn1565-3633-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/8722
dc.rightsDefault Licence-
dc.subjectbioinorganic chemistryen
dc.subjectorganotin(iv) compoundsen
dc.subjectmercapto amino acidsen
dc.subjectl-cysteineen
dc.subjectanti-tumour compoundsen
dc.subjectacetyl-l-cysteineen
dc.subjectamino-acidsen
dc.subjectcrystal-structureen
dc.subjectethyl-esteren
dc.subjectcomplexesen
dc.subjecttinen
dc.subjectpenicillamineen
dc.subjectmethionineen
dc.subjectligandsen
dc.titleOrganotin(IV) derivatives of L-cysteine and their in vitro anti-tumor propertiesen
heal.abstractThe synthesis and characterization of the organotin compounds [(n-C4H9)(2)Sn(cys)] (1), [(C6H5)(2)Sn(cys)] (2), [(C6H5)(3)Sn(Hcys).(H2O)] (3), {[(CH3)(2)Sn(KCYS)(2)].2(H2O)} (4), {[(n-C4H9)(2)Sn(KCYS)(2)].2(H2O)} (5) and {[(C6H5)(2)Sn(KCYS)(2)].2(H2O)} (6) (where H(2)cys= L-cysteine) are reported. The compounds have been characterized by elemental analysis and H-1-NMR, Uv-Vis, FT-IR and Mossbauer spectroscopic techniques. Attempted recrystallization of (2) in DMSO/methanol 2:1 solution yielded after several days unexpectedly the dimeric compound bis(tri-phenyltin)sulphide {[(C6H5)(3)Sn](2)S} (7) which has been characterized by x-ray analysis. The structure of the parent complex (2) as well as the mechanism of the decomposition of cysteine are being further investigated. The in vitro anticancer activity of complexes (1) - (6), against human leukemia (HL60), human liver (Bel7402), human stomach (BGC823) and human cervix epithelial human carcinoma (Hela), nasopharyngeal carcinoma (KB) and lung cancer (PG) tumor cells, were evaluated.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1155/S1565363304000044-
heal.identifier.secondary<Go to ISI>://000224303000004-
heal.identifier.secondaryhttp://downloads.hindawi.com/journals/bca/2004/418579.pdf-
heal.journalNameBioinorg Chem Applen
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2004-
heal.publisherFreund Publishing House Ltd.en
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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