Serum uric acid levels and risk for acute ischaemic non-embolic stroke in elderly subjects

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dc.contributor.authorMilionis, H. J.en
dc.contributor.authorKalantzi, K. J.en
dc.contributor.authorGoudevenos, J. A.en
dc.contributor.authorSeferiadis, K.en
dc.contributor.authorMikhailidis, D. P.en
dc.contributor.authorElisaf, M. S.en
dc.date.accessioned2015-11-24T18:52:00Z
dc.date.available2015-11-24T18:52:00Z
dc.identifier.issn0954-6820-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/18340
dc.rightsDefault Licence-
dc.subjectAgeden
dc.subjectBody Mass Indexen
dc.subjectBrain Ischemia/blooden
dc.subjectCase-Control Studiesen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectHypertension/blood/complicationsen
dc.subjectLipids/blooden
dc.subjectMaleen
dc.subjectMetabolic Syndrome X/blood/complicationsen
dc.subjectRisk Factorsen
dc.subjectSex Factorsen
dc.subjectStroke/*blood/etiologyen
dc.subjectUric Acid/*blooden
dc.titleSerum uric acid levels and risk for acute ischaemic non-embolic stroke in elderly subjectsen
heal.abstractBACKGROUND: Elevated serum uric acid (SUA) levels have been proposed as an independent risk factor for cardiovascular (CV) morbidity and mortality. Recent evidence suggests that treatments with a hypouricaemic action have a favourable effect on CV event prevention. OBJECTIVES: The association between SUA and acute ischaemic/non-embolic stroke was assessed in a population-based case-control study in the prefecture of Ioannina, Epirus, Greece. SUBJECTS AND METHODS: A total of 163 patients aged older than 70 years (88 men and 75 women) admitted due to a first-ever-in-a-lifetime acute ischaemic/non-embolic stroke and 166 volunteers (87 men and 79 women) without a history of CV disease were included. The association between SUA and stroke was determined by multivariate logistic regression modelling after adjusting for potential confounding factors. RESULTS: Stroke patients showed higher concentrations of SUA compared with controls (333.1+/-101.1 micromol L(-1) vs. 285.5+/-83.3 micromol L(-1); P<0.001). In univariate analysis elevated SUA levels were associated with increased risk for ischaemic stroke [odds ratio (OR) 1.42, 95% confidence interval (CI) 1.21-1.64, P<0.0001]. Compared to patients with SUA levels in the lowest quintile, those within the highest quintile had a 2.8-time increase in the odds of suffering an ischaemic stroke (OR 2.81, 95% CI 1.67-4.73, P<0.001). This association was strong even after controlling for gender, age, body mass index, the presence of hypertension and diabetes mellitus, drug treatment and lipids (OR 2.90, 95% CI 1.59-5.30, P=0.001). CONCLUSION: Elevated SUA is associated with an increased risk for acute ischaemic/non-embolic stroke in a strictly defined population of elderly individuals independently of concurrent metabolic derangements. This association may need to be considered when treating the elderly.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1111/j.1365-2796.2005.01565.x-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/16238679-
heal.identifier.secondaryhttp://onlinelibrary.wiley.com/store/10.1111/j.1365-2796.2005.01565.x/asset/j.1365-2796.2005.01565.x.pdf?v=1&t=h0lzzqmy&s=b321b8c4f7ef4e9f0314848b7522f9833b06eebc-
heal.journalNameJ Intern Meden
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2005-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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