Increased plasma levels of visfatin/pre-B cell colony-enhancing factor in obese and overweight patients with metabolic syndrome
| dc.contributor.author | Filippatos, T. D. | en |
| dc.contributor.author | Derdemezis, C. S. | en |
| dc.contributor.author | Kiortsis, D. N. | en |
| dc.contributor.author | Tselepis, A. D. | en |
| dc.contributor.author | Elisaf, M. S. | en |
| dc.date.accessioned | 2015-11-24T16:39:40Z | |
| dc.date.available | 2015-11-24T16:39:40Z | |
| dc.identifier.issn | 0391-4097 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/8180 | |
| dc.rights | Default Licence | - |
| dc.subject | visfatin | en |
| dc.subject | pre-b cell colony-enhancing factor | en |
| dc.subject | metabolic syndrome | en |
| dc.subject | obesity | en |
| dc.subject | triglycerides | en |
| dc.subject | homa index | en |
| dc.subject | micronized fenofibrate | en |
| dc.subject | diabetes-mellitus | en |
| dc.subject | combination | en |
| dc.subject | adipokine | en |
| dc.subject | fat | en |
| dc.title | Increased plasma levels of visfatin/pre-B cell colony-enhancing factor in obese and overweight patients with metabolic syndrome | en |
| heal.abstract | Background: Visfatin [pre-B cell colony-enhancing factor (PBEF)] is a cytokine highly expressed in visceral fat that exhibits insulin-mimetic properties. However, its role in insulin-resistant states, such as in metabolic syndrome (MetS), remains largely unknown. Objective: To investigate the possible differences of plasma visfatin levels between obese and overweight subjects with and without MetS. Design and patients: Plasma visfatin concentrations were measured with enzyme-linked immunosorbent assay (ELISA) in 28 overweight and obese [body mass index (BMI)>28 kg/m(2)] subjects with Mets and 28 age- and sex-matched overweight and obese (BMI>28 kg/m(2)) individuals without MetS (control group). Results: Patients with MetS exhibited significantly elevated waist circumference (WCR) values, higher blood pressure readings, higher fasting glucose and triglyceride concentrations as well as lower levels of HDL cholesterol (HDL-C) compared with controls. Total and LDL cholesterol (LDL-C) concentrations did not differ significantly between the two groups. Plasma visfatin concentrations were significantly higher in subjects with MetS compared with controls [27 (1665) ng/ml vs 19 (10-47) ng/ml, p<0.05]. The same results were observed even after adjustment for age, sex and BMI. Plasma visfatin levels were positively correlated with age (r=0.32, p<0.05), WCR (r=0.31, p<0.05), triglyceride (r=0.59, p<0.01) and glucose (r=0.33, p<0.05) levels and were negatively correlated with HDL-C levels (r=-0.38, p<0.05). Multiple linear regression analysis revealed similar results. Conclusion: Plasma visfatin levels are increased in overweight and obese subjects with MetS compared with those individuals who do not fulfil the criteria for the diagnosis of MetS. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | <Go to ISI>://000247380500013 | - |
| heal.journalName | Journal of Endocrinological Investigation | en |
| heal.journalType | peer reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2007 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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