Expression of p53, p21, mdm2, Rb, bax and Ki67 proteins in lymphomas of the mucosa-associated lymphoid (MALT) tissue

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dc.contributor.authorStefanaki, K.en
dc.contributor.authorTzardi, M.en
dc.contributor.authorKouvidou, C.en
dc.contributor.authorChaniotis, V.en
dc.contributor.authorBolioti, M.en
dc.contributor.authorVlychou, M.en
dc.contributor.authorZois, M.en
dc.contributor.authorKakolyris, S.en
dc.contributor.authorDelides, G.en
dc.contributor.authorRontogianni, D.en
dc.contributor.authorGeorgoulias, V.en
dc.contributor.authorKanavaros, P.en
dc.date.accessioned2015-11-24T19:16:35Z
dc.date.available2015-11-24T19:16:35Z
dc.identifier.issn0250-7005-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21683
dc.rightsDefault Licence-
dc.subjectCell Nucleus/pathologyen
dc.subjectCyclin-Dependent Kinase Inhibitor p21en
dc.subjectCyclins/*analysisen
dc.subjectEnzyme Inhibitors/analysisen
dc.subjectHumansen
dc.subjectImmunohistochemistryen
dc.subjectKi-67 Antigen/*analysisen
dc.subjectLymphoma, B-Cell, Marginal Zone/*pathologyen
dc.subjectNeoplasm Proteins/analysisen
dc.subject*Nuclear Proteinsen
dc.subjectProto-Oncogene Proteins/*analysisen
dc.subjectProto-Oncogene Proteins c-bcl-2/analysisen
dc.subjectProto-Oncogene Proteins c-mdm2en
dc.subjectRetinoblastoma Protein/*analysisen
dc.subjectTumor Suppressor Protein p53/*analysisen
dc.subjectbcl-2-Associated X Proteinen
dc.titleExpression of p53, p21, mdm2, Rb, bax and Ki67 proteins in lymphomas of the mucosa-associated lymphoid (MALT) tissueen
heal.abstractWe have investigated by immunohistochemistry 38 cases of B-cell MALT-NHL comprising 23 high grade (HG) and 15 low grade-(LG) tumours for the expression of p53, mdm2, p21, Rb, Ki67, bcl2 and Bax proteins. P53, mdm2 and p21 proteins were found in at least 5% of the tumour cells in 13/23, 2/23 and 11/23 HG tumours, respectively. These proteins were detected in very rare tumour cells in LG tumours. The following patterns were recorded in HG tumours: p53+/p21+/mdm2+ (2 cases), p53+/p21+/mdm2- (7 cases), p53+/p21-/mdm2- (4 cases), p53-/p21-/mdm2- (18 cases) and p53-/p21+/mdm2-(2 cases). Proliferative Ki67 index and Rb protein expression were higher in HG than in LG MALT-NHL. Bcl2 protein was expressed in all LG MALT-NHL, whereas only 2/23 HG MALT-NHL were bcl2 positive in most tumour cells. Bax protein was expressed in all MALT-NHL with HG tumours being positive in higher proportion of tumour cells than LG tumours. These findings show that significant expression of p53, mdm2, p21,Ki67 and Rb proteins occurs more frequently in aggressive histotypes of MALT-NHL. The parallel Rb/Ki67 expression suggests that Rb protein expression in MALT-NHL is normally regulated in relation to the proliferative growth fraction of the tumours. The pattern p53+/p21+/mdm2 +/- may represent MALT-NHL with wild type (wt) p53 gene since mdm2 and p21 proteins are inducible by wt p53 gene. The pattern p53+/mdm2-/p21-may represent MALT-NHL with p53 gene mutations unable to activate expression of mdm2 and p21 proteins. MALT-NHL with the p53-/mdm2-/p21 + pattern may be consistent with p53-independent p21 expression. Bax protein expression in all MALT-NHL suggests a role for this protein in the pathogenesis of these tumours.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/9703886-
heal.journalNameAnticancer Resen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1998-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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