Assessment of cumulative evidence on genetic associations: interim guidelines

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dc.contributor.authorIoannidis, J. P.en
dc.contributor.authorBoffetta, P.en
dc.contributor.authorLittle, J.en
dc.contributor.authorO'Brien, T. R.en
dc.contributor.authorUitterlinden, A. G.en
dc.contributor.authorVineis, P.en
dc.contributor.authorBalding, D. J.en
dc.contributor.authorChokkalingam, A.en
dc.contributor.authorDolan, S. M.en
dc.contributor.authorFlanders, W. D.en
dc.contributor.authorHiggins, J. P.en
dc.contributor.authorMcCarthy, M. I.en
dc.contributor.authorMcDermott, D. H.en
dc.contributor.authorPage, G. P.en
dc.contributor.authorRebbeck, T. R.en
dc.contributor.authorSeminara, D.en
dc.contributor.authorKhoury, M. J.en
dc.date.accessioned2015-11-24T19:35:15Z
dc.date.available2015-11-24T19:35:15Z
dc.identifier.issn1464-3685-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/23691
dc.rightsDefault Licence-
dc.subject*Epidemiologic Studiesen
dc.subjectEvaluation Studies as Topicen
dc.subjectEvidence-Based Medicineen
dc.subjectFemaleen
dc.subject*Genetic Heterogeneityen
dc.subjectGenetic Predisposition to Disease/*epidemiologyen
dc.subject*Guidelines as Topicen
dc.subjectHeterozygote Detectionen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectSensitivity and Specificityen
dc.titleAssessment of cumulative evidence on genetic associations: interim guidelinesen
heal.abstractEstablished guidelines for causal inference in epidemiological studies may be inappropriate for genetic associations. A consensus process was used to develop guidance criteria for assessing cumulative epidemiologic evidence in genetic associations. A proposed semi-quantitative index assigns three levels for the amount of evidence, extent of replication, and protection from bias, and also generates a composite assessment of 'strong', 'moderate' or 'weak' epidemiological credibility. In addition, we discuss how additional input and guidance can be derived from biological data. Future empirical research and consensus development are needed to develop an integrated model for combining epidemiological and biological evidence in the rapidly evolving field of investigation of genetic factors.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1093/ije/dym159-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/17898028-
heal.identifier.secondaryhttp://ije.oxfordjournals.org/content/37/1/120.full.pdf-
heal.journalNameInt J Epidemiolen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2008-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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