Induction Chemotherapy with Docetaxel and Cisplatin Followed by Concomitant Chemoradiotherapy in Patients with Inoperable Non-nasopharyngeal Carcinoma of the Head and Neck
Φόρτωση...
Ημερομηνία
Συγγραφείς
Fountzilas, G.
Bamias, A.
Kalogera-Fountzila, A.
Karayannopoulou, G.
Bobos, M.
Athanassiou, E.
Kalogeras, K. T.
Tolis, C.
Tsekeris, P.
Papakostas, P.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Anticancer Res
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Background: Induction chemotherapy (IC) followed by concomitant chemoradiotherapy (CCRT) has the potential of being an ideal multi-modality approach for improving the prognosis of patients with squamous cell carcinoma of the head and neck (SSCHN). Patients and Methods: Thirty-four patients with locally advanced SCCHN were treated with 3 cycles of IC, consisting of docetaxel 75 mg/m(2) and cisplatin 75 mg/m(2) even 3 weeks, followed 3-4 weeks later by definitive radiotherapy (70 Gy) and concomitant weekly cisplatin 40 mg/m(2). Results: After a median follow-up of 27.7 months, 6-month progression-free survival (PFS), the primary study end-point, was 84%. The median PFS was 16.4 months and median overall survival 24.4 months. The majority of the patients completed 3 cycles of IC with mild to moderate toxicity. Anemia, nausea/vomiting and mucositis were the prominent toxicities during CCRT Retrospective analysis of a panel of biomarkers suggested that excision repair cross-complementation group 1 (ERCC1) protein expression was associated with shorter PFS. Conclusion: IC followed by CCRT as administered in the present study, is a feasible and well-tolerated therapeutic approach. However, its real impact on the prognosis of SCCHN patients has to be demonstrated in a randomized study comparing this treatment to CCRT alone.
Περιγραφή
Λέξεις-κλειδιά
head and neck cancer, chemotherapy, radiation therapy, docetaxel, ercc1, squamous-cell carcinoma, growth-factor receptor, locally advanced head, group phase-ii, immunohistochemical evidence, chemoradiation paradigm, protein overexpression, pten expression, poor-prognosis, lung-cancer
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
<Go to ISI>://000263731300012
http://ar.iiarjournals.org/content/29/2/529.full.pdf
http://ar.iiarjournals.org/content/29/2/529.full.pdf
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών και Τεχνολογιών. Τμήμα Βιολογικών Εφαρμογών και Τεχνολογιών