Fenofibrate plus simvastatin (fixed-dose combination) for the treatment of dyslipidaemia
Φόρτωση...
Ημερομηνία
Συγγραφείς
Filippatos, T. D.
Elisaf, M. S.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Expert Opin Pharmacother
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
INTRODUCTION: Statin use results in a significant reduction of cardiovascular disease (CVD) risk. However, patients still have residual CVD risk, even if they are receiving optimal statin treatment. AREAS COVERED: This review, based on a Pubmed/Scopus search, discusses the available evidence regarding the use of a fixed-dose fenofibrate plus simvastatin combination. This combination is useful for patients with mixed dyslipidaemia because it improves the overall lipoprotein profile. Although in clinical trials the rate of adverse events was not significantly greater than monotherapy, patients who receive combination treatment should be monitored carefully. Furthermore, in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Study, this combination did not result in a significant reduction of CVD events compared with simvastatin monotherapy. However, a possible benefit in this trial was observed in the subgroup of patients with high triglyceride and low high-density lipoprotein cholesterol levels. EXPERT OPINION: The fixed-dose fenofibrate plus simvastatin combination treatment produces additive results and is safe when patients are properly monitored. Existing evidence appears to support the addition of fenofibrate to simvastatin treatment for the reduction of residual CVD risk in patients with atherogenic dyslipidaemia. However, this combination did not lead to better clinical outcomes in the absence of dyslipidaemia.
Περιγραφή
Λέξεις-κλειδιά
Adult, Cardiovascular Diseases/epidemiology, Diabetes Complications/blood/drug therapy/metabolism, Drug Combinations, Drug Monitoring, Dyslipidemias/blood/*drug therapy/metabolism, Fenofibrate/*administration & dosage/adverse effects/therapeutic use, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors/*administration & dosage/adverse, effects/therapeutic use, Hypertriglyceridemia/blood/drug therapy/metabolism, Hypolipidemic Agents/*administration & dosage/adverse effects/therapeutic use, Lipoproteins/blood, Risk Factors, Simvastatin/*administration & dosage/adverse effects/therapeutic use
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/21736529
http://informahealthcare.com/doi/abs/10.1517/14656566.2011.593509
http://informahealthcare.com/doi/abs/10.1517/14656566.2011.593509
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής