Photophysical properties of Hypericum perforatum L. extracts - Novel photosensitizers for PDT

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dc.contributor.authorSkalkos, D.en
dc.contributor.authorGioti, E.en
dc.contributor.authorStalikas, C. D.en
dc.contributor.authorMeyer, H.en
dc.contributor.authorPapazoglou, T. G.en
dc.contributor.authorFilippidis, G.en
dc.date.accessioned2015-11-24T16:44:50Z
dc.date.available2015-11-24T16:44:50Z
dc.identifier.issn1011-1344-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/8840
dc.rightsDefault Licence-
dc.subjecthypericum perforatum l. (st. john's wort) (hp)en
dc.subjecthypericinen
dc.subjectphotodynamic therapy (pdt)en
dc.subjectphotodynamic diagnosis (pdd)en
dc.subjectphotodynamic therapyen
dc.subjectbladderen
dc.subjectfluorescenceen
dc.subjectcarcinomaen
dc.subjectcellsen
dc.subjectphen
dc.titlePhotophysical properties of Hypericum perforatum L. extracts - Novel photosensitizers for PDTen
heal.abstractWe report the preparation of the methanolic extract (ME), and polar methanolic fraction (PMF) from the plant Hypericum perforatum L. The extracts contain various photosensitizing constituents such as naphthodianthrone derivatives (in 1.37% w/w), and chlorophylls (in 0.08% w/w). Upon light emission these constituents can be activated, providing photodynamic properties to the extracts, and making them a potent, new class, natural photosensitizers for use in photodynamic therapy (PDT), and photodynamic diagnosis (PDD). The absorbance spectra of the extracts are similar to the spectrum of hypericin, the main naphthodianthrone identified within, with two major bands at 548 and 590 nm. The fluorescence spectra in ethanol exhibit two main bands around 595 and 640 nm, in accordance with the spectrum of pure hypericin. The fluorescence intensity of PMF at 595 nm is only eight times less than the intensity of pure hypericin at the same wavelength, even though its hypericin concentration is only 0.57% w/w. The dependence of the PMF fluorescence signal on the pH of the medium, alone and in comparison with the signal of hypericin, has been investigated. PMF signal fades steadily, and smoothly both in acidic, and basic environment. (c) 2005 Elsevier B.V. All rights reserved.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primaryDOI 10.1016/j.jphotobiol.2005.11.001-
heal.identifier.secondary<Go to ISI>://000234959400008-
heal.identifier.secondaryhttp://ac.els-cdn.com/S1011134405002046/1-s2.0-S1011134405002046-main.pdf?_tid=5c4aa220b5323c977a1d6f318e515964&acdnat=1333040931_a4b7240ebaf1d4ae50d07a23a07508ff-
heal.journalNameJournal of Photochemistry and Photobiology B-Biologyen
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2006-
heal.publisherElsevieren
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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