Antibodies against various forms of mildly oxidized low-density lipoprotein are not associated with carotid intima-media thickness in patients with primary hyperlipidemia

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dc.contributor.authorTsouli, S. G.en
dc.contributor.authorKiortsis, D. N.en
dc.contributor.authorXydis, V.en
dc.contributor.authorArgyropoulou, M. I.en
dc.contributor.authorElisaf, M.en
dc.contributor.authorTselepis, A. D.en
dc.date.accessioned2015-11-24T16:50:28Z
dc.date.available2015-11-24T16:50:28Z
dc.identifier.issn0003-3197-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/9610
dc.rightsDefault Licence-
dc.subjectactivating factor-acetylhydrolaseen
dc.subjectpaf-acetylhydrolaseen
dc.subjectldlen
dc.subjectatherosclerosisen
dc.subjectautoantibodiesen
dc.subjectoxidationen
dc.subjectrisken
dc.subjecthypertensionen
dc.subjectcholesterolen
dc.subjectmacrophagesen
dc.titleAntibodies against various forms of mildly oxidized low-density lipoprotein are not associated with carotid intima-media thickness in patients with primary hyperlipidemiaen
heal.abstractThe carotid intima-media thickness (IMT) can reflect early atherosclerosis. Oxidative modification of low-density lipoprotein (LDL) leads to the formation of several immunogenic epitopes and different forms of antibodies against oxidized LDL (oxLDL). We investigated the possible relationship between autoantibody titers against various forms of mildly oxLDL and carotid IMT in patients (n = 100) with primary hyperlipidemia. Three different types of mildly oxidized LDL - oxLDL(L), oxLDL(P), and oxLDL(D)-were prepared at the end of lag, propagation, and decomposition phases of oxidation, respectively. Similar types of oxLDL were also prepared from the same LDL preparations after inactivation of the LDL-associated platelet-activating factor acetylhydrolase (PAF-AH). These types were denoted as oxLDL(-)L, oxLDL(-)P, and oxLDL(-)D. OxLDL types are primarily enriched in lysophosphatidylcholine (lyso-PC) due to hydrolysis of oxidized phospholipids (oxPL) by PAF-AH. OxLDL(-) types are mainly enriched in intact oxPL due to the inactivation of the LDL-associated PAF-AH before oxidation. IgG autoantibodies against all types of oxLDL were determined and IMT was evaluated ultrasonographically. IMT values were significantly associated with age, systolic blood pressure and serum triglyceride levels, whereas no correlation was found between IMT values and antibody titers against all types of either oxLDL or oxLDL(-). We suggest that autoantibodies against various types of mildly oxidized LDL enriched either in lyso-PC or in oxPL are not associated with the extent of carotid atherosclerosis. This supports the concept that extensively oxidized LDL enriched in aldehydes rather than mildly oxidized LDL may play a prominent role in the early stage of atherosclerosis.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primaryDoi 10.1177/0003319706293142-
heal.identifier.secondary<Go to ISI>://000241425200011-
heal.identifier.secondaryhttp://ang.sagepub.com/content/57/5/615.full.pdf-
heal.journalNameAngiologyen
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2006-
heal.publisherSageen
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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