Biweekly administration of 24-h infusion of irinotecan followed by a 1-h infusion of docetaxel: a phase I study
Φόρτωση...
Ημερομηνία
Συγγραφείς
Briasoulis, E.
Pentheroudakis, G.
Timotheadou, H.
Rammou, D.
Pavlidis, N.
Fountzilas, G.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Anticancer Drugs
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
We developed a chemotherapy combination regimen based on preclinical data suggesting synchronization of cancer cells in G2/M phase when exposed to irinotecan over a protracted period. This phase I study aimed to determine the toxicity spectrum, and define the dose-limiting toxicity (DLT), maximum tolerated dose (MTD) and recommended optimal dose (ROD) of irinotecan infused over 24 h and followed by a 1-h infusion of 30 mg/m2 docetaxel. Starting dose for irinotecan was 30 mg/m2 and escalation proceeded at 30 mg/m2 increments, in cohorts of three to six patients until the MTD was reached. A dose between the MTD and the previous level was explored to further define the ROD. Thirty-two patients with advanced refractory cancers (median age 64, 19 male) received 190 treatment courses at five dosing levels of irinotecan: 30 mg/m2 (n=6 patients), 60 (n=3), 90 (n=7), 120 (n=8) and 105 (n=8). The MTD and ROD was 120/30 and 105/30 mg/m2. DLTs were diarrhea and neutropenia. Antitumor activity was modest. The ROD of biweekly administration of 24-h irinotecan followed by 1-h docetaxel is 105 and 30 mg/m2, respectively. The low hematological toxicity and modest activity observed leave questions concerning the optimal timing of this combination.
Περιγραφή
Λέξεις-κλειδιά
Antineoplastic Combined Chemotherapy Protocols/administration & dosage/adverse, effects/*therapeutic use, Camptothecin/administration & dosage/adverse effects/*analogs &, derivatives/*therapeutic use, Clinical Trials, Phase II as Topic, Diarrhea/chemically induced, Dose-Response Relationship, Drug, *Drug Administration Schedule, Female, Greece, Hematologic Diseases/chemically induced, Humans, Infusions, Intravenous/*methods, Male, Middle Aged, Patient Selection, Taxoids/administration & dosage/adverse effects/*therapeutic use, Time Factors, Treatment Outcome, Withholding Treatment/ethics
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/15494635
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής