Phospholipase A(2) subclasses in acute respiratory distress syndrome
| dc.contributor.author | Kitsiouli, E. | en |
| dc.contributor.author | Nakos, G. | en |
| dc.contributor.author | Lekka, M. E. | en |
| dc.date.accessioned | 2015-11-24T16:44:29Z | |
| dc.date.available | 2015-11-24T16:44:29Z | |
| dc.identifier.issn | 0925-4439 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/8807 | |
| dc.rights | Default Licence | - |
| dc.subject | ali | en |
| dc.subject | ards | en |
| dc.subject | phospholipase a(2) | en |
| dc.subject | pla(2) | en |
| dc.subject | paf-ah | en |
| dc.subject | lung surfactant | en |
| dc.subject | inhibitors of pla(2) | en |
| dc.subject | acute lung injury | en |
| dc.subject | platelet-activating-factor | en |
| dc.subject | arachidonic-acid release | en |
| dc.subject | surfactant protein-a | en |
| dc.subject | bronchoalveolar lavage fluid | en |
| dc.subject | airway epithelial-cells | en |
| dc.subject | intestinal ischemia-reperfusion | en |
| dc.subject | x secreted phospholipase-a(2) | en |
| dc.subject | smooth-muscle-cells | en |
| dc.subject | m-type receptor | en |
| dc.title | Phospholipase A(2) subclasses in acute respiratory distress syndrome | en |
| heal.abstract | phospholipases A(2), (PLA(2)) catalyse the cleavage of fatty acids esterified at the sn-2 position of glycerophospholipids. In acute lung injury-acute respiratory distress syndrome (ALI-ARDS) several distinct isoenzymes appear in lung cells and fluid Some are capable to trigger molecular events leading to enhanced inflammation and lung damage and others have a role in lung surfactant recycling preserving lung function Secreted forms (groups sPLA(2)-IIA, -V, -X) can directly hydrolyze surfactant phospholipids Cytosolic PLA(2) (cPLA(2)-IVA) requiring Ca(2+) has a preference for arachidonate, the precursor of etcosanoids which participate in the inflammatory response in the lung. Ca(2+) independent intracellular PLA(2)s (iPLA(2)) take part in surfactant phospholipids turnover within alveolar cells Acidic Ca(2+) -independent PLA(2) (aiPLA(2)). of lysosomal origin. has additionally antioxidant properties, (peroxiredoxin VI activity). and participates in the formation of dipalmitoyl-phosphatidylcholine in lung surfactant. PAF-AH degrades PAF. a potent mediator of inflammation, and oxidatively fragmented phospholipids but also leads to toxic metabolites. Therefore, the regulation of PLA(2) isoforms could be a valuable approach for ARDS treatment. (C) 2009 Elsevier B.V All rights reserved. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | DOI 10.1016/j.bbadis.2009.06.007 | - |
| heal.identifier.secondary | <Go to ISI>://000271071600002 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/S0925443909001380/1-s2.0-S0925443909001380-main.pdf?_tid=25588c005c8a30f4395b2acd39f5691a&acdnat=1333033686_41946e413ba999479a179718bb8def8c | - |
| heal.journalName | Biochimica Et Biophysica Acta-Molecular Basis of Disease | en |
| heal.journalType | peer reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2009 | - |
| heal.publisher | Elsevier | en |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
Αρχεία
Φάκελος/Πακέτο αδειών
1 - 1 of 1
Φόρτωση...
- Ονομα:
- license.txt
- Μέγεθος:
- 1.74 KB
- Μορφότυπο:
- Item-specific license agreed upon to submission
- Περιγραφή: