Coelomic fluid leptin concentration in normal first-trimester pregnancies and missed miscarriages
| dc.contributor.author | Makrydimas, G. | en |
| dc.contributor.author | Vandecruys, H. | en |
| dc.contributor.author | Sotiriadis, A. | en |
| dc.contributor.author | Lakasing, L. | en |
| dc.contributor.author | Spencer, K. | en |
| dc.contributor.author | Nicolaides, K. H. | en |
| dc.date.accessioned | 2015-11-24T19:30:06Z | |
| dc.date.available | 2015-11-24T19:30:06Z | |
| dc.identifier.issn | 1015-3837 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/23019 | |
| dc.rights | Default Licence | - |
| dc.subject | Abortion, Missed/*metabolism | en |
| dc.subject | Amniotic Fluid/*metabolism | en |
| dc.subject | Female | en |
| dc.subject | Fetal Death/metabolism | en |
| dc.subject | Humans | en |
| dc.subject | Leptin/blood/*metabolism | en |
| dc.subject | Oxygen/metabolism | en |
| dc.subject | Placenta/metabolism | en |
| dc.subject | Pregnancy | en |
| dc.subject | Pregnancy Trimester, First/*metabolism | en |
| dc.title | Coelomic fluid leptin concentration in normal first-trimester pregnancies and missed miscarriages | en |
| heal.abstract | OBJECTIVE: Investigation of the possible role of leptin in early pregnancy failure. METHODS: Leptin concentration was measured in maternal serum, coelomic fluid and amniotic fluid from 15 singleton pregnancies with live fetuses and 7 missed miscarriages at 7-10 weeks of gestation. RESULTS: In the pregnancies with live fetuses, the median leptin concentration was significantly higher in coelomic fluid (median 33.1 ng/ml) than in maternal serum (median 8.1 ng/ml) or amniotic fluid (median 0.5 ng/ml). In the pregnancies with missed miscarriage, compared to those with live fetuses, the median leptin concentration in coelomic fluid was higher (median 45.3 ng/ml), but in maternal serum it was not significantly different (median 5.5 ng/ml). CONCLUSIONS: The high coelomic fluid leptin concentration suggests that embryonic death may be preceded by impaired oxygenation of the placenta that stimulates production of leptin. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | 10.1159/000086821 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/16113562 | - |
| heal.identifier.secondary | http://content.karger.com/ProdukteDB/produkte.asp?doi=10.1159/000086821 | - |
| heal.journalName | Fetal Diagn Ther | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2005 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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