Patients with psoriasis are more likely to be treated for latent tuberculosis infection prior to biologics than patients with inflammatory bowel disease

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dc.contributor.authorBassukas, I. D.en
dc.contributor.authorKosmidou, M.en
dc.contributor.authorGaitanis, G.en
dc.contributor.authorTsiouri, G.en
dc.contributor.authorTsianos, E.en
dc.date.accessioned2015-11-24T18:59:51Z
dc.date.available2015-11-24T18:59:51Z
dc.identifier.issn1651-2057-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/19428
dc.rightsDefault Licence-
dc.subjectAdolescenten
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAnalysis of Varianceen
dc.subjectAntitubercular Agents/*administration & dosageen
dc.subjectBiological Agents/*administration & dosageen
dc.subjectColitis, Ulcerative/diagnosis/immunology/*therapyen
dc.subjectCrohn Disease/diagnosis/immunology/*therapyen
dc.subjectDrug Administration Scheduleen
dc.subjectFalse Positive Reactionsen
dc.subjectFemaleen
dc.subjectGreeceen
dc.subjectHumansen
dc.subjectLatent Tuberculosis/diagnosis/*drug therapy/immunologyen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectPractice Guidelines as Topicen
dc.subjectPredictive Value of Testsen
dc.subjectPsoriasis/diagnosis/immunology/*therapyen
dc.subjectRetrospective Studiesen
dc.subjectSeverity of Illness Indexen
dc.subjectTime Factorsen
dc.subjectTuberculin Testen
dc.subjectTumor Necrosis Factor-alpha/*antagonists & inhibitorsen
dc.subjectYoung Adulten
dc.titlePatients with psoriasis are more likely to be treated for latent tuberculosis infection prior to biologics than patients with inflammatory bowel diseaseen
heal.abstractScreening for latent tuberculosis infection (LTBI) is recommended before treatment with biologics is initiated in patients with psoriasis or inflammatory bowel disease (IBD). Our objective was to evaluate the effect of underlying disease (psoriasis or IBD) on the risk of LTBI diagnosis prior to anti-tumor necrosis factor-alpha (TNF-alpha) therapy. During a two-year period LTBI diagnosis rate was compared in consecutive patients with psoriasis or IBD (Crohn's disease or ulcerative colitis). IBD patients (n = 33) had significantly smaller tuberculin skin testing compared to psoriasis patients (n = 30) (p = 0.007). Applying LTBI diagnosis guidelines resulted in more psoriasis (50%) than IBD patients (24.2%) receiving treatment for LTBI prior to onset of anti-TNF-alpha treatment (p = 0.04). In conclusion, current recommendations for LTBI diagnosis must be re-evaluated to account for the unique tuberculin hyperactive state of the skin of patients with psoriasis.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.2340/00015555-1106-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/21547342-
heal.journalNameActa Derm Venereolen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2011-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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