Tetranectin expression in gastric adenocarcinomas

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dc.contributor.authorArvanitis, D. L.en
dc.contributor.authorKamper, E. F.en
dc.contributor.authorKopeikina, L.en
dc.contributor.authorStavridou, A.en
dc.contributor.authorSgantzos, M. N.en
dc.contributor.authorKallioras, V.en
dc.contributor.authorAthanasiou, E.en
dc.contributor.authorKanavaros, P.en
dc.date.accessioned2015-11-24T19:42:41Z
dc.date.available2015-11-24T19:42:41Z
dc.identifier.issn0213-3911-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/24678
dc.rightsDefault Licence-
dc.subjectAdenocarcinoma/*metabolism/pathologyen
dc.subjectAdenocarcinoma, Mucinous/*metabolism/pathologyen
dc.subjectBlood Proteins/*biosynthesisen
dc.subjectCarcinoma, Signet Ring Cell/*metabolism/pathologyen
dc.subjectHumansen
dc.subject*Lectins, C-Typeen
dc.subjectStomach/*metabolism/pathologyen
dc.subjectStomach Neoplasms/*metabolism/pathologyen
dc.titleTetranectin expression in gastric adenocarcinomasen
heal.abstractAIMS: The aim was to analyze the immunohistochemical localization of tetranectin in gastric adenocarcinomas and the adjacent tissues of the wall of the stomach. METHODS AND RESULTS: Forty cases of gastric adenocarcinomas were stained by the indirect immunoperoxidase method. Of the ten cases of mucinous signet ring cell carcinomas 5 showed high, 3 moderate and 2 low tetranectin expression. Of the ten cases of well-differentiated intestinal type adenocarcinomas (ITA) 4 showed moderate regional, 3 low regional and 3 negative tetranectin expression. Of the ten cases of moderately-differentiated ITA 3 showed moderate regional, 4 low regional and 3 negative tetranectin expression. Of the ten cases of poorly-differentiated ITA 4 showed focal low and 6 negative tetranectin expression. Overall, the mucinous signet ring carcinomas showed significantly higher tetranectin expression compared to ITA (chi2 = 3.95, p<0.05). In contrast, no significant relationship was found between tetranectin expression and the degree of differentiation in ITA (chi2 = 2.5, p>0.05). In all cases, the perineoplastic desmoplastic reactive stroma showed high expression of tetranectin intra- and extracellularly. The mast cells and goblet cells in the areas of intestinal metaplasia showed high tetranectin expression. CONCLUSIONS: This study shows that: a) tetranectin is produced and deposited extracellularly in the desmoplastic peritumoral stroma of infiltrating gastric adenocarcinomas; b) tetranectin is more highly expressed by the mucinous signet ring cell carcinomas compared to ITA; and c) the amount of tetranectin produced by the ITA is unrelated with the degree of tumor differentiation.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/11962752-
heal.journalNameHistol Histopatholen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2002-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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