Replication in genome-wide association studies
| dc.contributor.author | Kraft, P. | en |
| dc.contributor.author | Zeggini, E. | en |
| dc.contributor.author | Ioannidis, J. P. | en |
| dc.date.accessioned | 2015-11-24T18:54:13Z | |
| dc.date.available | 2015-11-24T18:54:13Z | |
| dc.identifier.issn | 0883-4237 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/18659 | |
| dc.rights | Default Licence | - |
| dc.title | Replication in genome-wide association studies | en |
| heal.abstract | Replication helps ensure that a genotype-phenotype association observed in a genome-wide association (GWA) study represents a credible association and is not a chance finding or an artifact due to uncontrolled biases. We discuss prerequisites for exact replication; issues of heterogeneity; advantages and disadvantages of different methods of data synthesis across multiple studies; frequentist vs. Bayesian inferences for replication; and challenges that arise from multi-team collaborations. While consistent replication can greatly improve the credibility of a genotype-phenotype association, it may not eliminate spurious associations due to biases shared by many studies. Conversely, lack of replication in well-powered follow-up studies usually invalidates the initially proposed association, although occasionally it may point to differences in linkage disequilibrium or effect modifiers across studies. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | 10.1214/09-STS290 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/20454541 | - |
| heal.identifier.secondary | http://projecteuclid.org/DPubS?service=UI&version=1.0&verb=Display&handle=euclid.ss/1271770349 | - |
| heal.journalName | Stat Sci | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2009 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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