Prognostic utility of beta-tubulin isotype III and correlations with other molecular and clinicopathological variables in patients with early breast cancer: a translational Hellenic Cooperative Oncology Group (HeCOG) study

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dc.contributor.authorPentheroudakis, G.en
dc.contributor.authorBatistatou, A.en
dc.contributor.authorKalogeras, K. T.en
dc.contributor.authorKronenwett, R.en
dc.contributor.authorWirtz, R. M.en
dc.contributor.authorBournakis, E.en
dc.contributor.authorEleftheraki, A. G.en
dc.contributor.authorPectasides, D.en
dc.contributor.authorBobos, M.en
dc.contributor.authorPapaspirou, I.en
dc.contributor.authorKamina, S.en
dc.contributor.authorGogas, H.en
dc.contributor.authorKoutras, A. K.en
dc.contributor.authorPavlidis, N.en
dc.contributor.authorFountzilas, G.en
dc.date.accessioned2015-11-24T18:56:12Z
dc.date.available2015-11-24T18:56:12Z
dc.identifier.issn1573-7217-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/18999
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAgeden
dc.subjectBreast Neoplasms/*diagnosis/genetics/mortality/*pathologyen
dc.subjectFemaleen
dc.subjectGene Expression Profilingen
dc.subjectGene Expression Regulation, Neoplasticen
dc.subjectHumansen
dc.subjectMiddle Ageden
dc.subjectMultivariate Analysisen
dc.subjectNeoplasm Stagingen
dc.subjectPredictive Value of Testsen
dc.subjectPrognosisen
dc.subjectRNA, Messenger/metabolismen
dc.subjectRetrospective Studiesen
dc.subjectSurvival Analysisen
dc.subjectTubulin/genetics/*metabolismen
dc.subjectYoung Adulten
dc.titlePrognostic utility of beta-tubulin isotype III and correlations with other molecular and clinicopathological variables in patients with early breast cancer: a translational Hellenic Cooperative Oncology Group (HeCOG) studyen
heal.abstractWe evaluated the prognostic and predictive utility of beta-tubulin isotype III (TUBB3) tumour gene transcription in early breast cancer patients enrolled in a randomised study. Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was applied for assessment of TUBB3, ER, PgR, HER2 and MAPT messenger RNA and immunohistochemistry (IHC) for protein expression in 314 patients enrolled in trial HE10/97, evaluating epirubicin-alkylator adjuvant chemotherapy with or without paclitaxel. High TUBB3 mRNA status was associated with advanced T stage, high histological grade, low mRNA and protein levels of ER, PgR and MAPT, and high levels of HER2 (p < 0.001). At a median follow-up of 98 months, multivariate analysis showed high TUBB3 mRNA status to have prognostic significance for DFS (HR = 1.83, 95% CI 1.25-2.68, p = 0.002) and OS (HR = 1.71, 95% CI 1.03-2.83, p = 0.038), along with the number of involved axillary nodes, PgR mRNA status and tumour grade. TUBB3 mRNA levels did not predict benefit from inclusion of paclitaxel in adjuvant chemotherapy (test for interaction p = 0.96 for OS, p = 0.46 for DFS). Transcriptional activity of beta-tubulin isotype III in early breast cancer is an adverse prognostic factor, though not a predictive one for taxane efficacy.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1007/s10549-011-1427-0-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/21390496-
heal.identifier.secondaryhttp://www.springerlink.com/content/k742834357227315/fulltext.pdf-
heal.journalNameBreast Cancer Res Treaten
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2011-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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