Cell cycle and apoptosis deregulation in classical Hodgkin lymphomas

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dc.contributor.authorBai, M.en
dc.contributor.authorPapoudou-Bai, A.en
dc.contributor.authorKitsoulis, P.en
dc.contributor.authorHorianopoulos, N.en
dc.contributor.authorKamina, S.en
dc.contributor.authorAgnantis, N. J.en
dc.contributor.authorKanavaros, P.en
dc.date.accessioned2015-11-24T19:31:21Z
dc.date.available2015-11-24T19:31:21Z
dc.identifier.issn0258-851X-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/23250
dc.rightsDefault Licence-
dc.subjectApoptosis/*physiologyen
dc.subjectB-Lymphocytes/physiologyen
dc.subjectCell Cycle/*physiologyen
dc.subjectCell Differentiation/physiologyen
dc.subjectEpstein-Barr Virus Infections/complicationsen
dc.subjectHerpesvirus 4, Human/physiologyen
dc.subjectHodgkin Disease/*pathology/virologyen
dc.subjectHumansen
dc.subjectReed-Sternberg Cells/physiologyen
dc.subjectSignal Transduction/physiologyen
dc.titleCell cycle and apoptosis deregulation in classical Hodgkin lymphomasen
heal.abstractClassical Hodgkin lymphomas (cHL) have now been recognized as B-cell lymphomas with some exceptional cases of T-cell origin. In recent years, there has been accumulating evidence that Hodgkin and Reed-Sternberg (H/RS) cells, the presumed neoplastic-cell population in cHL, are characterized by a profound disturbance of the cell cycle and apoptosis regulation. The constitutive activation of the nuclear factor (NF)-kappaB pathway, which is considered to be involved in the proliferation and survival of H/RS cells. Moreover, substantial evidence that H/RS cells have defective cell cycle and apoptosis regulation has been provided by studies showing that these cells are characterized, in a large proportion of cases, by alterations of the p53, Rb and p27 tumor suppressor pathways, overexpression of cyclins involved in the G1/S and G2/M transition such as cyclins E, D2, D3, A and B1, overexpression of cyclin-dependent kinases such as CDK1, 2 and 6 and overexpression of anti-apoptotic proteins such as c-FLIP, bcl-xl, c-IAP2, X-linked I4P and survivin. Recent studies suggest that interleukin 13 (IL-13) is an important growth and survival factor in H/RS cells. Furthermore, the Epstein-Barr Virus (EBV), which is present in H/RS cells in about 30-50% of cHL, has been shown to affect the cell cycle and apoptosis regulation in cHL. The present review summarizes data with respect to the cell cycle and apoptosis deregulation in cHL.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/15796209-
heal.journalNameIn Vivoen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2005-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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