Significance of aphasia after first-ever acute stroke: impact on early and late outcomes
| dc.contributor.author | Tsouli, S. | en |
| dc.contributor.author | Kyritsis, A. P. | en |
| dc.contributor.author | Tsagalis, G. | en |
| dc.contributor.author | Virvidaki, E. | en |
| dc.contributor.author | Vemmos, K. N. | en |
| dc.date.accessioned | 2015-11-24T18:51:36Z | |
| dc.date.available | 2015-11-24T18:51:36Z | |
| dc.identifier.issn | 1423-0208 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/18281 | |
| dc.rights | Default Licence | - |
| dc.subject | Aged | en |
| dc.subject | Aphasia/*etiology/mortality/therapy | en |
| dc.subject | Cause of Death | en |
| dc.subject | Cohort Studies | en |
| dc.subject | Female | en |
| dc.subject | Glasgow Coma Scale | en |
| dc.subject | Greece/epidemiology | en |
| dc.subject | Hospitalization | en |
| dc.subject | Humans | en |
| dc.subject | Hypertension/complications/epidemiology | en |
| dc.subject | Kaplan-Meier Estimate | en |
| dc.subject | Male | en |
| dc.subject | Proportional Hazards Models | en |
| dc.subject | Prospective Studies | en |
| dc.subject | Risk Factors | en |
| dc.subject | Stroke/*complications/mortality/therapy | en |
| dc.subject | Treatment Outcome | en |
| dc.title | Significance of aphasia after first-ever acute stroke: impact on early and late outcomes | en |
| heal.abstract | BACKGROUND: We assessed the incidence and determinants of aphasia attributable to first-ever acute stroke. We also investigated early and long-term mortality and 1-year dependence in post-stroke patients. METHODS: A 10-year prospective hospital-based study was conducted in the prefecture of Athens, Greece. RESULTS: In total, 2,297 patients were included in the study, of whom 806 (35.1%) had aphasia. The presence of aphasia was independently associated with increasing age (OR: 1.19 per 10-year increase, 95% CI: 1.12-1.21) and atrial fibrillation (OR: 1.35, 95% CI: 1.08-1.67), and inversely associated with Scandinavian Stroke Scale (SSS) score (OR: 0.55 per 10-point increase, 95% CI: 0.52-0.59) and hypertension (OR: 0.77, 95% CI: 0.63-0.96). One-year dependence score (calculated with the modified Rankin score) was higher in aphasic patients compared to non-aphasics (p < 0.001). Moreover, severity of aphasia (estimated with a subscale of SSS) was found as an independent predictor of 1-year dependence. Most of the deaths in the aphasic patients were attributed to infections and neurological damage. Using the Kaplan-Meier limit method, the unadjusted probability of 10-year mortality was demonstrated to increase with the severity of aphasia (log-rank test: 233.9, p < 0.001) and, even after adjustment for several other factors, severity of aphasia remained an independent predictor of 10-year mortality. CONCLUSIONS: Increasing age, atrial fibrillation and severity of stroke were associated with the risk of aphasia after stroke. Severity of aphasia is a strong predictor of long-term mortality and dependence of post-stroke patients. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | 10.1159/000222091 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/19494550 | - |
| heal.identifier.secondary | http://content.karger.com/ProdukteDB/produkte.asp?doi=10.1159/000222091 | - |
| heal.journalName | Neuroepidemiology | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2009 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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