Effects of terlipressin and somatostatin on liver and thorax blood volumes in patients with cirrhosis
| dc.contributor.author | Kalambokis, G. | en |
| dc.contributor.author | Tsiouris, S. | en |
| dc.contributor.author | Tsianos, E. V. | en |
| dc.contributor.author | Baltayiannis, G. | en |
| dc.contributor.author | Pakou, B. | en |
| dc.contributor.author | Fotopoulos, A. | en |
| dc.date.accessioned | 2015-11-24T19:20:28Z | |
| dc.date.available | 2015-11-24T19:20:28Z | |
| dc.identifier.issn | 1478-3231 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/22041 | |
| dc.rights | Default Licence | - |
| dc.subject | Esophageal and Gastric Varices/drug therapy/etiology/physiopathology | en |
| dc.subject | Female | en |
| dc.subject | Gamma Cameras | en |
| dc.subject | Hemodynamics/drug effects | en |
| dc.subject | Hormones/*therapeutic use | en |
| dc.subject | Humans | en |
| dc.subject | Hypertension, Portal/complications/drug therapy/physiopathology | en |
| dc.subject | Infusions, Intravenous | en |
| dc.subject | Liver Circulation/*drug effects | en |
| dc.subject | Liver Cirrhosis/complications/*drug therapy/physiopathology | en |
| dc.subject | Lypressin/*analogs & derivatives/therapeutic use | en |
| dc.subject | Male | en |
| dc.subject | Middle Aged | en |
| dc.subject | Radiopharmaceuticals/diagnostic use | en |
| dc.subject | Somatostatin/*therapeutic use | en |
| dc.subject | Technetium Tc 99m Sestamibi/diagnostic use | en |
| dc.subject | Thorax/*blood supply/radionuclide imaging | en |
| dc.subject | Vasoconstrictor Agents/*therapeutic use | en |
| dc.title | Effects of terlipressin and somatostatin on liver and thorax blood volumes in patients with cirrhosis | en |
| heal.abstract | BACKGROUND: Variceal bleeding in cirrhosis can cause liver ischaemia and deteriorate the hyperdynamic state; thus, the effects of vasoconstrictor therapy on liver blood volume (LBV) and thorax blood volume (ThBV) are important. AIM: To evaluate and compare the effects of terlipressin and somatostatin on LBV and ThBV in stable patients with cirrhosis and portal hypertension. METHODS: Twenty patients were studied (Child-Pugh class A/B/C: 5/8/7). The radioactivities in the liver region (LRR) and the thorax region (ThRR) by single-head gamma camera technique, as indicators of LBV and ThBV, respectively, and systemic haemodynamics were measured at baseline and after intravenous infusion of 2 mg of terlipressin (n=10) or somatostatin 250 mg/h after an initial bolus of 250 mg (n=10). RESULTS: LRR and ThRR decreased significantly with increasing severity of cirrhosis. Thirty minutes after terlipressin infusion, LRR and ThRR increased by 7.8 +/- 4.4% (NS) and 14 +/- 5.3% (P=0.01) compared with baseline values; the increase in ThRR was significantly related to the increase in LRR (r=0.682, P=0.03). In contrast, somatostatin reduced LRR and ThRR by 13.3 +/- 6.5% (P=0.07) and 1 +/- 4% (NS) respectively. LRR and ThRR increased significantly in the terlipressin group compared with the somatostatin group (P=0.01 and P=0.02 respectively). Terlipressin reduced cardiac output and heart rate (both P=0.01) and increased the mean arterial pressure (MAP) and systemic vascular resistance (P=0.009 and P=0.002 respectively); MAP decreased after somatostatin infusion (P=0.03). CONCLUSIONS: Terlipressin, but not somatostatin, maintains LBV, increases ThBV and improves the hyperdynamic state in cirrhosis. These effects can be beneficial in variceal bleeding, particularly in patients with advanced liver disease. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | 10.1111/j.1478-3231.2010.02322.x | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/20738780 | - |
| heal.identifier.secondary | http://onlinelibrary.wiley.com/store/10.1111/j.1478-3231.2010.02322.x/asset/j.1478-3231.2010.02322.x.pdf?v=1&t=h0ulxvka&s=4e5a272cc1b41389924c2d613433097c3ef15e36 | - |
| heal.journalName | Liver Int | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2010 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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