Clinicopathological study of the expression of syndecan-1 in invasive breast carcinomas. correlation with extracellular matrix components

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dc.contributor.authorTsanou, E.en
dc.contributor.authorIoachim, E.en
dc.contributor.authorBriasoulis, E.en
dc.contributor.authorCharchanti, A.en
dc.contributor.authorDamala, K.en
dc.contributor.authorKaravasilis, V.en
dc.contributor.authorPavlidis, N.en
dc.contributor.authorAgnantis, N. J.en
dc.date.accessioned2015-11-24T19:30:12Z
dc.date.available2015-11-24T19:30:12Z
dc.identifier.issn0392-9078-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/23041
dc.rightsDefault Licence-
dc.subjectAvidin/chemistryen
dc.subjectBasement Membrane/metabolismen
dc.subjectBiotin/chemistryen
dc.subjectBreast Neoplasms/*metabolism/pathologyen
dc.subjectCarcinoma/pathologyen
dc.subjectCarcinoma, Ductal, Breast/*metabolism/pathologyen
dc.subjectCell Adhesionen
dc.subjectCell Line, Tumoren
dc.subjectCell Membrane/metabolismen
dc.subjectCell Proliferationen
dc.subjectCohort Studiesen
dc.subjectCollagen Type IV/metabolismen
dc.subjectDisease Progressionen
dc.subjectDisease-Free Survivalen
dc.subjectExtracellular Matrix/*metabolismen
dc.subjectFibroblast Growth Factor 2/metabolismen
dc.subjectHumansen
dc.subjectImmunohistochemistryen
dc.subjectLymphatic Metastasisen
dc.subjectMembrane Glycoproteins/*biosynthesisen
dc.subjectNeoplasm Invasivenessen
dc.subjectNeoplasm Metastasisen
dc.subjectNeoplasms/metabolismen
dc.subjectProteoglycans/*biosynthesisen
dc.subjectReceptors, Progesterone/metabolismen
dc.subjectStreptavidin/chemistryen
dc.subjectSyndecan-1en
dc.subjectSyndecansen
dc.subjectTenascin/metabolismen
dc.subjectTime Factorsen
dc.subjectTumor Suppressor Protein p53/metabolismen
dc.titleClinicopathological study of the expression of syndecan-1 in invasive breast carcinomas. correlation with extracellular matrix componentsen
heal.abstractSyndecan-1, a cell surface proteoglycan found predominantly on epithelia of mature tissues, binds both extracellular matrix (ECM) components and basic fibroblast growth factor (bFGF) and is implicated in the restriction of growth and invasiveness of neoplastic cells, as it induces the adhesion capacity of neoplastic cells with the stroma. In this study we investigated breast carcinomas for the immunohistochemical expression of syndecan-1 protein and these results were assessed in relation to clinicopathological parameters, in order to clarify its prognostic value. The possible relationship with hormone receptors content, p53, cell proliferation markers, and extracellular matrix components was also estimated. Tissue sections from 102 breast carcinomas were used and immunostainings were performed on formalin-fixed, paraffin-embedded tissue sections by the labelled streptavidin avidin biotin (LSAB) method. High expression levels were observed, as 75/102 (73.5%) cases expressed immunoreactivity in more than 80% of neoplastic cells, while 67/102 (65.7%) exhibited high staining intensity. The survival analysis showed an increased mortality risk associated with high syndecan-1 staining intensity with borderline significance (p=0.041). In addition, there was a strong negative correlation between syndecan-1 protein expression and ECM, specifically collagen IV (p=0.026) and tenascin (p=0.0067). The results of the present study show the implication of this protein in the remodeling of breast cancer tissue, through the interaction with other extracellular matrix components, probably influences the tumour progression.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/15743035-
heal.journalNameJ Exp Clin Cancer Resen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2004-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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