The systemic inflammatory response in coronary artery bypass grafting: what is the role of the very low ejection fraction (EF <= 30%)?

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dc.contributor.authorKarfis, E. A.en
dc.contributor.authorPapadopoulos, G.en
dc.contributor.authorMatsagas, M.en
dc.contributor.authorPantazi, D.en
dc.contributor.authorLekka, M.en
dc.contributor.authorKitsiouli, I.en
dc.contributor.authorSiminelakis, S.en
dc.contributor.authorAnagnostopoulos, C. E.en
dc.contributor.authorDrossos, G.en
dc.date.accessioned2015-11-24T16:51:13Z
dc.date.available2015-11-24T16:51:13Z
dc.identifier.issn0021-9509-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/9707
dc.rightsDefault Licence-
dc.subjectcoronary artery bypassen
dc.subjectcytokinesen
dc.subjecttumor necrosis factor-alphaen
dc.subjecttumor-necrosis-factoren
dc.subjectcardiopulmonary bypassen
dc.subjectcytokine responsesen
dc.subjectproinflammatory cytokinesen
dc.subjectcardiac transplantationen
dc.subjectheart-failureen
dc.subjectsurgeryen
dc.subjectreleaseen
dc.subjectinterleukin-10en
dc.subjectreperfusionen
dc.titleThe systemic inflammatory response in coronary artery bypass grafting: what is the role of the very low ejection fraction (EF <= 30%)?en
heal.abstractAim. Patients with depressed left ventricular function are more susceptible to develop postoperative complications after cardiac surgery. The aim of the present study was to examine the effect of severe left ventricular dysfunction on the activation of systemic inflammatory reaction during and after coronary artery bypass grafting (CABG). Methods. Clinical prospective study; 32 selected patients underwent CABG; 16 patients had depressed left ventricular function before the operation (low ejection fraction [EF] <30%) - Low EF group (study group). Sixteen patients had normal left ventricular function (normal EF, >50%) - Normal EF group (control group). The levels of inflammatory mediators TNF-alpha IL-6, IL-8 and IL-10 were measured preoperatively, during and after cardiopulmonary bypass (CPB) and 24 hours postoperatively. Results. Higher levels of almost all of inflammatory mediators were detected in patients with depressed left ventricular function compared with patients of normal EF group. IL-6 levels were found statistically significant higher in Low EF group before the induction of anesthesia (P=0.039) and after the administration of protamine (P=0.02). IL-8 levels were found statistically significant higher in Low EF group before the induction of anesthesia (P=0.05), 30 min after the start of CPB (P=0.02), after the administration of protamine (P=0.015) and 24 hours after the end of the operation (P=0.05). No statistically significant differences were demonstrated between the 2 groups of study relative to TNF-alpha and IL-10. Conclusion. A greater activation of systemic inflammatory reaction occurred in patients with depressed left ventricular function than in patients with normal cardiac function when they underwent CABG with extracorporeal circulation.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondary<Go to ISI>://000263041000014-
heal.journalNameJournal of Cardiovascular Surgeryen
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2008-
heal.publisherEdizione Minerva Medicaen
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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