Profound LH suppression after GnRH antagonist administration is associated with a significantly higher ongoing pregnancy rate in IVF

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dc.contributor.authorKolibianakis, E. M.en
dc.contributor.authorZikopoulos, K.en
dc.contributor.authorSchiettecatte, J.en
dc.contributor.authorSmitz, J.en
dc.contributor.authorTournaye, H.en
dc.contributor.authorCamus, M.en
dc.contributor.authorVan Steirteghem, A. C.en
dc.contributor.authorDevroey, P.en
dc.date.accessioned2015-11-24T18:56:24Z
dc.date.available2015-11-24T18:56:24Z
dc.identifier.issn0268-1161-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/19033
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectChorionic Gonadotropin/therapeutic useen
dc.subjectEmbryo Implantationen
dc.subjectFemaleen
dc.subjectFertilization in Vitro/*methodsen
dc.subjectFollicle Stimulating Hormone/therapeutic useen
dc.subjectGonadotropin-Releasing Hormone/administration & dosage/*analogs &en
dc.subjectderivatives/*antagonists & inhibitors/*pharmacologyen
dc.subjectHormone Antagonists/administration & dosage/*pharmacologyen
dc.subjectHumansen
dc.subjectLuteinizing Hormone/*blood/drug effectsen
dc.subjectOocytes/drug effects/physiologyen
dc.subjectPregnancyen
dc.subject*Pregnancy Rateen
dc.subjectProspective Studiesen
dc.subjectRegression Analysisen
dc.titleProfound LH suppression after GnRH antagonist administration is associated with a significantly higher ongoing pregnancy rate in IVFen
heal.abstractBACKGROUND: The significance of suppressed LH levels in GnRH antagonist cycles for IVF outcome is currently unknown. The purpose of this study was to evaluate prospectively the association between LH levels and ongoing pregnancy achievement after GnRH antagonist initiation in IVF cycles. METHODS: Ovarian stimulation with a fixed dose of 200 IU recombinant FSH and daily GnRH antagonist (ganirelix) 0.25 mg from day 6 of stimulation was initiated in 116 women. Patients were not pretreated with an oral contraceptive. Induction of final oocyte maturation was performed with HCG 10,000 IU as soon as three follicles of > or =17 mm were present in ultrasound, and was followed by oocyte pick-up, conventional IVF or ICSI, and embryo transfer. The luteal phase was supplemented with vaginal progesterone. RESULTS: A significant decrease of both ongoing pregnancy rate and implantation rate was present across groups of patients with increasing LH levels. The highest implantation rate and ongoing pregnancy rate was present in those patients with LH levels on day 8 of stimulation < or =0.5 IU/l. CONCLUSIONS: Profound suppression of LH on day 8 of stimulation is associated with a significantly higher chance of achieving an ongoing pregnancy. More studies are necessary to evaluate this phenomenon further.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1093/humrep/deh471-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/15319383-
heal.identifier.secondaryhttp://humrep.oxfordjournals.org/content/19/11/2490.full.pdf-
heal.journalNameHum Reproden
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2004-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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