Prevention of atrial fibrillation with omega-3 fatty acids: a meta-analysis of randomised clinical trials
| dc.contributor.author | Liu, T. | en |
| dc.contributor.author | Korantzopoulos, P. | en |
| dc.contributor.author | Shehata, M. | en |
| dc.contributor.author | Li, G. | en |
| dc.contributor.author | Wang, X. | en |
| dc.contributor.author | Kaul, S. | en |
| dc.date.accessioned | 2015-11-24T18:56:43Z | |
| dc.date.available | 2015-11-24T18:56:43Z | |
| dc.identifier.issn | 1468-201X | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/19081 | |
| dc.rights | Default Licence | - |
| dc.subject | Atrial Fibrillation/diagnosis/*prevention & control | en |
| dc.subject | *Dietary Supplements | en |
| dc.subject | Fatty Acids, Omega-3/*therapeutic use | en |
| dc.subject | Humans | en |
| dc.subject | Randomized Controlled Trials as Topic | en |
| dc.subject | Research Design | en |
| dc.title | Prevention of atrial fibrillation with omega-3 fatty acids: a meta-analysis of randomised clinical trials | en |
| heal.abstract | CONTEXT: Previous randomised controlled trials (RCT) regarding n-3 PUFA supplementation for atrial fibrillation (AF) prevention have yielded conflicting results. OBJECTIVE: A systematic review and meta-analysis of RCT was conducted to examine the role of n-3 PUFA in AF prevention. DATA SOURCES: MEDLINE, Web of Science and Cochrane clinical trials database were searched until November 2010. STUDY SELECTION: Of 127 initially identified studies, 10 RCT with 1955 patients were finally analysed. DATA EXTRACTION: Two blinded reviewers extracted data independently to a predefined form. Disagreements were resolved through discussion and consensus. RESULTS: n-3 PUFA had no significant effect on the prevention of AF (OR 0.81, 95% CI 0.57 to 1.15; p=0.24). There was significant heterogeneity among the studies (p=0.002, I(2)=65.0%). Subgroup analysis showed no significant beneficial effect of fish oils in any subset of population. CONCLUSIONS: No significant effects of n-3 PUFA supplementation on AF prevention were observed in this meta-analysis. A large-scale trial with higher doses and longer follow-up might be required to rule out the possibility of any treatment benefit. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | 10.1136/hrt.2010.215350 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/21478384 | - |
| heal.identifier.secondary | http://heart.bmj.com/content/97/13/1034 | - |
| heal.journalName | Heart | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2011 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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