Use of interferon-gamma release assay for latent tuberculosis infection screening in older adults exposed to tuberculosis in a nursing home

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dc.contributor.authorKatsenos, S.en
dc.contributor.authorNikolopoulou, M.en
dc.contributor.authorGartzonika, C.en
dc.contributor.authorManda-Stachouli, C.en
dc.contributor.authorGogali, A.en
dc.contributor.authorGrypaiou, C.en
dc.contributor.authorMavridis, A.en
dc.contributor.authorConstantopoulos, S. H.en
dc.contributor.authorDaskalopoulos, G.en
dc.date.accessioned2015-11-24T18:55:29Z
dc.date.available2015-11-24T18:55:29Z
dc.identifier.issn1532-5415-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/18887
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAged, 80 and overen
dc.subjectCross Infection/diagnosisen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectInterferon-gamma/*diagnostic useen
dc.subjectLatent Tuberculosis/*diagnosisen
dc.subjectMaleen
dc.subjectMass Screening/*methodsen
dc.subject*Nursing Homesen
dc.subjectTuberculin Test/*methodsen
dc.titleUse of interferon-gamma release assay for latent tuberculosis infection screening in older adults exposed to tuberculosis in a nursing homeen
heal.abstractOBJECTIVES: To assess the additive value of a newly marketed interferon-gamma release assay, QuantiFERON-TB Gold In-Tube (QFT-GIT), to a single tuberculin skin test (TST) for the detection of latent tuberculosis infection (LTBI) in older adults who have been exposed to TB in a nursing home. DESIGN: Contact tracing included clinical examination, chest radiography, TST, and QFT-GIT in TST-negative people (TST< 5 mm). SETTING: A private nursing home. PARTICIPANTS: Seventy-seven individuals (63 elderly residents, 14 young employees) who had been exposed to an active TB case in a private nursing home. MEASUREMENTS: Comparison of TST and QFT-GIT in older adults who have been exposed to TB. RESULTS: For the TST, the positive response rate was 31.7% (n=20) of elderly residents and 43% (n=6) of staff. Positive QFT-GIT results were obtained in seven (16.3%) elderly residents with negative TST, six of whom were aged 80 and older. QFT-GIT increased the percentage of possible LTBI in this group from 31.7% to 42.9%. CONCLUSION: QFT-GIT has a significant additive value to single TST for detecting LTBI in institutionalized older adults, identifying infected subjects anergic to the TST.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1111/j.1532-5415.2011.03367.x-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/21517785-
heal.identifier.secondaryhttp://onlinelibrary.wiley.com/store/10.1111/j.1532-5415.2011.03367.x/asset/j.1532-5415.2011.03367.x.pdf?v=1&t=h0p345tj&s=2b14964563701bf69e51d752a1b371c2273730e3-
heal.journalNameJ Am Geriatr Socen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2011-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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