Biological studies of organotin(IV) complexes with 2-mercaptopyrimidine

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dc.contributor.authorXanthopoulou, M. N.en
dc.contributor.authorHadjikakou, S. K.en
dc.contributor.authorHadjiliadis, N.en
dc.contributor.authorKourkoumelis, N.en
dc.contributor.authorMilaeva, E. R.en
dc.contributor.authorGracheva, Y. A.en
dc.contributor.authorTyurin, V. Y.en
dc.contributor.authorVerginadis, I.en
dc.contributor.authorKarkabounas, S.en
dc.contributor.authorBaril, M.en
dc.contributor.authorButler, I. S.en
dc.date.accessioned2015-11-24T16:53:10Z
dc.date.available2015-11-24T16:53:10Z
dc.identifier.issn1066-5285-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/9982
dc.rightsDefault Licence-
dc.subjectbioinorganic chemistryen
dc.subjectcomplexesen
dc.subjectorganotin(iv) complexesen
dc.subject2-mercaptopyrimidineen
dc.subjectlipoxygenasesen
dc.subjectantitumor activityen
dc.subjectcrystal-structureen
dc.subjectlinoleic-aciden
dc.subjectderivativesen
dc.subjecttinen
dc.titleBiological studies of organotin(IV) complexes with 2-mercaptopyrimidineen
heal.abstractThe known organotin(IV) complexes with 2-mercaptopyrimidine (L) [Me2SnL2] (1), [Bu2SnL2] (2), [Ph2SnL2] (3), and [Ph3SnL] (4) were synthesized using a new approach. The effect of the synthesized compounds on peroxidation of fatty acids (oleic and linoleic) was studied. Complexes 1-4 promote the peroxidation of oleic acid. Their effect on the enzymatic peroxidation of linoleic acid with lipoxygenase was compared with that of cisplatin and in vitro cytoxicity against sarcoma cancer cells was determined. The antiproliferative effect of complexes 2-4 was demonstrated.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primaryDOI 10.1007/s11172-007-0115-z-
heal.identifier.secondary<Go to ISI>://000249952200016-
heal.identifier.secondaryhttp://www.springerlink.com/content/qm5825544418844m/fulltext.pdf-
heal.journalNameRussian Chemical Bulletinen
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2007-
heal.publisherSpringeren
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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