Pituitary adrenal responsiveness to corticotropin-releasing hormone in chronic uremic patients

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dc.contributor.authorSiamopoulos, K. C.en
dc.contributor.authorDardamanis, M.en
dc.contributor.authorKyriaki, D.en
dc.contributor.authorPappas, M.en
dc.contributor.authorSferopoulos, G.en
dc.contributor.authorAlevisou, V.en
dc.date.accessioned2015-11-24T18:58:22Z
dc.date.available2015-11-24T18:58:22Z
dc.identifier.issn0896-8608-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/19273
dc.rightsDefault Licence-
dc.subjectAdrenocorticotropic Hormone/blooden
dc.subjectCorticotropin-Releasing Hormone/*diagnostic useen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectHydrocortisone/blooden
dc.subjectHypothalamo-Hypophyseal System/*physiopathologyen
dc.subjectKidney Failure, Chronic/*physiopathology/therapyen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subject*Peritoneal Dialysis, Continuous Ambulatoryen
dc.subjectPituitary-Adrenal System/*physiopathologyen
dc.subjectRadioimmunoassayen
dc.subjectRenal Dialysisen
dc.titlePituitary adrenal responsiveness to corticotropin-releasing hormone in chronic uremic patientsen
heal.abstractWe investigated the effect of exogenous ovine corticotropin-releasing hormone (oCRH) on plasma levels of adrenocorticotropic hormone (ACTH) and cortisol in 24 chronic renal failure patients: 8 nondialysis (NDCRF), 8 on hemodialysis (HD), and 8 on continuous ambulatory peritoneal dialysis (CAPD). In all groups the acute administration of oCRH caused a further increase (less pronounced in NDCRF patients) in the already elevated levels of cortisol. Following oCRH administration, plasma ACTH rose significantly in CAPD patients, but there was a blunted response of the hormone in the NDCRF and HD groups. The patterns of the ACTH and cortisol response in the last two groups, resemble those observed in chronic stress. We conclude that the hypothalamic-pituitary-adrenal axis in chronic uremic patients, retains the ability to respond to exogenous oCRH. Patients on CAPD, however, display a better, identical to normal response, which can be due to less chronic stress and/or to the more effective clearance of uremic toxins.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/1964805-
heal.journalNamePerit Dial Inten
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1990-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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