Shared epitopes and rheumatoid arthritis: disease associations in Greece and meta-analysis of Mediterranean European populations

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dc.contributor.authorIoannidis, J. P.en
dc.contributor.authorTarassi, K.en
dc.contributor.authorPapadopoulos, I. A.en
dc.contributor.authorVoulgari, P. V.en
dc.contributor.authorBoki, K. A.en
dc.contributor.authorPapasteriades, C. A.en
dc.contributor.authorDrosos, A. A.en
dc.date.accessioned2015-11-24T18:51:47Z
dc.date.available2015-11-24T18:51:47Z
dc.identifier.issn0049-0172-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/18306
dc.rightsDefault Licence-
dc.subjectAdolescenten
dc.subjectAdulten
dc.subjectAgeden
dc.subjectArthritis, Rheumatoid/epidemiology/ genetics/physiopathologyen
dc.subjectFemaleen
dc.subjectGenetic Predisposition to Diseaseen
dc.subjectGreece/epidemiologyen
dc.subjectHistocompatibility Antigens Class II/ geneticsen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectMediterranean Region/epidemiologyen
dc.subjectMiddle Ageden
dc.subjectSeverity of Illness Indexen
dc.titleShared epitopes and rheumatoid arthritis: disease associations in Greece and meta-analysis of Mediterranean European populationsen
heal.abstractOBJECTIVES: To assess the strength of the associations between HLA shared epitopes (SE) and rheumatoid arthritis (RA) susceptibility, articular disease severity, and extra-articular features in Mediterranean European populations. METHODS: One hundred and seventy-four Greek RA patients and 103 controls were evaluated. Data were then included in a meta-analysis of 9 studies of Mediterranean European populations (959 RA patients and 1,405 controls). RESULTS: In our study population, SE alleles were significantly more common in RA patients than in controls (odds ratio [OR], 2.5; 95% confidence interval [CI], 1.4-4.3). Larsen radiologic score was predicted by SE and disease duration. SE did not increase the risk of any extra-articular manifestation. The meta-analysis showed a pooled OR of 3.7 (95% CI, 2.6-5.2) for susceptibility to RA conferred by SE (OR, 3.4 v 3.9 in Greek v non-Greek populations). CONCLUSIONS: SE determine articular destruction without increasing the risk of extra-articular manifestations. The immunogenetic associations of RA susceptibility are consistent, but their strength may depend on the SE prevalence in different ethnic groups.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://ac.els-cdn.com/S004901720200001X/1-s2.0-S004901720200001X-main.pdf?_tid=5a4b9aa2-c83e-11e2-826b-00000aacb361&acdnat=1369818270_dbdea779d0df52f927ea30c455f99325-
heal.journalNameSemin Arthritis Rheumen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2002-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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