Insights into the genetic architecture of osteoarthritis from stage 1 of the arcOGEN study

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dc.contributor.authorPanoutsopoulou, K.en
dc.contributor.authorSoutham, L.en
dc.contributor.authorElliott, K. S.en
dc.contributor.authorWrayner, N.en
dc.contributor.authorZhai, G.en
dc.contributor.authorBeazley, C.en
dc.contributor.authorThorleifsson, G.en
dc.contributor.authorArden, N. K.en
dc.contributor.authorCarr, A.en
dc.contributor.authorChapman, K.en
dc.contributor.authorDeloukas, P.en
dc.contributor.authorDoherty, M.en
dc.contributor.authorMcCaskie, A.en
dc.contributor.authorOllier, W. E. R.en
dc.contributor.authorRalston, S. H.en
dc.contributor.authorSpector, T. D.en
dc.contributor.authorValdes, A. M.en
dc.contributor.authorWallis, G. A.en
dc.contributor.authorWilkinson, J. M.en
dc.contributor.authorArden, E.en
dc.contributor.authorBattley, K.en
dc.contributor.authorBlackburn, H.en
dc.contributor.authorBlanco, F. J.en
dc.contributor.authorBumpstead, S.en
dc.contributor.authorCupples, L. A.en
dc.contributor.authorDay-Williams, A. G.en
dc.contributor.authorDixon, K.en
dc.contributor.authorDoherty, S. A.en
dc.contributor.authorEsko, T.en
dc.contributor.authorEvangelou, E.en
dc.contributor.authorFelson, D.en
dc.contributor.authorGomez-Reino, J. J.en
dc.contributor.authorGonzalez, A.en
dc.contributor.authorGordon, A.en
dc.contributor.authorGwilliam, R.en
dc.contributor.authorHalldorsson, B. V.en
dc.contributor.authorHauksson, V. B.en
dc.contributor.authorHofman, A.en
dc.contributor.authorHunt, S. E.en
dc.contributor.authorIoannidis, J. P. A.en
dc.contributor.authorIngvarsson, T.en
dc.contributor.authorJonsdottir, I.en
dc.contributor.authorJonsson, H.en
dc.contributor.authorKeen, R.en
dc.contributor.authorKerkhof, H. J. M.en
dc.contributor.authorKloppenburg, M. G.en
dc.contributor.authorKoller, N.en
dc.contributor.authorLakenberg, N.en
dc.contributor.authorLane, N. E.en
dc.contributor.authorLee, A. T.en
dc.contributor.authorMetspalu, A.en
dc.contributor.authorMeulenbelt, I.en
dc.contributor.authorNevitt, M. C.en
dc.contributor.authorO'Neill, F.en
dc.contributor.authorParimi, N.en
dc.contributor.authorPotter, S. C.en
dc.contributor.authorRego-Perez, I.en
dc.contributor.authorRiancho, J. A.en
dc.contributor.authorSherburn, K.en
dc.contributor.authorSlagboom, P. E.en
dc.contributor.authorStefansson, K.en
dc.contributor.authorStyrkarsdottir, U.en
dc.contributor.authorSumillera, M.en
dc.contributor.authorSwift, D.en
dc.contributor.authorThorsteinsdottir, U.en
dc.contributor.authorTsezou, A.en
dc.contributor.authorUitterlinden, A. G.en
dc.contributor.authorvan Meurs, J. B. J.en
dc.contributor.authorWatkins, B.en
dc.contributor.authorWheeler, M.en
dc.contributor.authorMitchell, S.en
dc.contributor.authorZhu, Y.en
dc.contributor.authorZmuda, J. M.en
dc.contributor.authorZeggini, E.en
dc.contributor.authorLoughlin, J.en
dc.contributor.authorarcOGEN Consortiumen
dc.date.accessioned2015-11-24T18:26:51Z
dc.date.available2015-11-24T18:26:51Z
dc.identifier.issn0003-4967-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/15967
dc.rightsDefault Licence-
dc.subjectgenome-wide associationen
dc.subjecthanden
dc.titleInsights into the genetic architecture of osteoarthritis from stage 1 of the arcOGEN studyen
heal.abstractObjectives The genetic aetiology of osteoarthritis has not yet been elucidated. To enable a well-powered genome-wide association study (GWAS) for osteoarthritis, the authors have formed the arcOGEN Consortium, a UK-wide collaborative effort aiming to scan genome-wide over 7500 osteoarthritis cases in a two-stage genome-wide association scan. Here the authors report the findings of the stage 1 interim analysis. Methods The authors have performed a genome-wide association scan for knee and hip osteoarthritis in 3177 cases and 4894 population-based controls from the UK. Replication of promising signals was carried out in silico in five further scans (44 449 individuals), and de novo in 14 534 independent samples, all of European descent. Results None of the association signals the authors identified reach genome-wide levels of statistical significance, therefore stressing the need for corroboration in sample sets of a larger size. Application of analytical approaches to examine the allelic architecture of disease to the stage 1 genome-wide association scan data suggests that osteoarthritis is a highly polygenic disease with multiple risk variants conferring small effects. Conclusions Identifying loci conferring susceptibility to osteoarthritis will require large-scale sample sizes and well-defined phenotypes to minimise heterogeneity.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primaryDOI 10.1136/ard.2010.141473-
heal.identifier.secondary<Go to ISI>://000289070500026-
heal.identifier.secondaryhttp://ard.bmj.com/content/70/5/864.full.pdf-
heal.journalNameAnn Rheum Disen
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2011-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών και Τεχνολογιών. Τμήμα Βιολογικών Εφαρμογών και Τεχνολογιώνel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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