Perioperative thyroid hormone kinetics in patients undergoing major oral and maxillofacial operations
Φόρτωση...
Ημερομηνία
Συγγραφείς
Saranteas, T.
Tachmintzis, A.
Katsikeris, N.
Lykoudis, E.
Mourouzis, I.
Anteriotis, D.
Alexopoulos, C.
Dimakopoulou, A.
Dimitriou, V.
Pantos, C.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
J Oral Maxillofac Surg
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
PURPOSE: The aim of this study was to investigate the perioperative response of serum thyroid hormones in patients who underwent extensive maxillofacial operations with desflurane (0.2 to 1.5 MAC) and remifentanil (0.05 to 0.3 microg/kg/min) anesthesia. MATERIALS AND METHODS: Serum thyroxine, total and free triiodothyronine, thyroid-stimulating hormone, interleukin-1beta and 6, TNF-alpha, free fatty acids, S100B protein, CRP, as well as amyloid A protein were measured in 13 patients subjected to extensive oral and maxillofacial operations. Samples were collected before anesthesia induction, at the end, and 6, 12, 24, and 72 hours after the end of surgery. Patients during the study fasted, and at the postoperative period received Ringer's saline or with 5% dextrose alternatively, at the rate of 0.5 to 1.5 mL/kg/hr. RESULTS: Thyroid hormones concentrations showed a significant decrease over time whereas their values recovered to the baseline 72 hours after surgery. Interleukin 1beta, 6, S100B protein, CRP, serum amyloid A protein, and free fatty acids showed a significant increase 6, 12, and 24 hours after the end of the operation as related to the basal value. No significant clinical complications were recorded over the study. CONCLUSION: Patients undergoing extensive oral and maxillofacial surgery exhibit marked decrease in serum thyroid hormones. Stress response, anesthesia, and perioperative fasting may be decisive factors eliciting this response. These metabolic derangements do not deteriorate the clinical outcome and subsequently may be an adaptive response for energy preservation in various organs.
Περιγραφή
Λέξεις-κλειδιά
Acute-Phase Proteins/analysis, Adult, Aged, Analysis of Variance, Anesthesia, Dental/methods, Cytokines/blood, Dental Stress Analysis, Fasting/blood, Female, Humans, Hypothalamo-Hypophyseal System/*physiology, Kinetics, Male, Middle Aged, Monitoring, Intraoperative, *Oral Surgical Procedures, Statistics, Nonparametric, Stress, Physiological/*blood, Thyroid Gland/*physiology, Thyroid Hormones/*blood, Thyrotropin/blood
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/17307585
http://ac.els-cdn.com/S0278239106013814/1-s2.0-S0278239106013814-main.pdf?_tid=51ef2896e39d3fba70c1c2a8876b42e3&acdnat=1333466353_a7de72c3b7cae6ef2123b1fb12b5bfea
http://ac.els-cdn.com/S0278239106013814/1-s2.0-S0278239106013814-main.pdf?_tid=51ef2896e39d3fba70c1c2a8876b42e3&acdnat=1333466353_a7de72c3b7cae6ef2123b1fb12b5bfea
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής